相关实验视频

Updated: Jan 11, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

过早出生成人的长期内分泌问题:系统性审查

T Claffey¹, A Cullinan¹, J Downey¹

¹Discipline of Paediatrics, Trinity College Dublin, the University of Dublin, Dublin, Ireland.

Frontiers in pediatrics

|November 17, 2025

概括

过早生育与成年期的许多长期内分泌问题有关,包括生长,甲状腺和代谢问题. 这一系统性审查强调了对早产儿进行持续健康监测的必要性.

科学领域:

内分泌学在内分泌学.
公共卫生公共卫生
系统审查是系统的审查.

背景情况:

过早生育是成人慢性疾病的重要危险因素.
过早分娩占爱尔兰所有分娩的7%,影响成人医疗保健.
本综述侧重于早产的成年人的长期内分泌结果.

研究的目的:

综合关于早产成年人长期内分泌相关结果的证据.
为了确定与早产相关的特定内分泌功能障碍.

主要方法:

对PubMed和Web of Science数据库的系统审查.
纳入标准侧重于成人内分泌结果 (海马体-垂体轴,生长,甲状腺,上腺,胰岛素敏感性,脂质代谢,心脏代谢病理,骨健康).
根据PRISMA标准的指导,在选了1584篇论文后,包括了27项研究.

主要成果:

过早生育是各种成人内分泌问题的重要危险因素.
相关结果包括身高下降,下丘脑-垂体轴功能障碍,生育能力降低,骨矿物质密度降低,甲状腺功能低下风险增加.
心脏代谢结果 (11/27项研究) 显示与糖尿病风险增加,胰岛素敏感性降低,身体脂肪增加和脂质失调有关.

结论:

过早生育与多个领域 (骨,甲状腺,生长,繁殖,新陈代谢) 的长期内分泌功能障碍有关.
这些综合数据凸显了对早产儿的长期成人随访的必要性.
早期识别和管理内分泌风险对这一群体至关重要.

关键词:

上腺上腺上腺骨头骨头骨头骨头内分泌-内分泌-内分泌-内分泌-内分泌长期的长期的长期的这是一种代谢性代谢.时间过早的早产.生殖健康生殖健康甲状腺是什么?甲状腺是什么?

更多相关视频

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

Published on: January 7, 2018

相关概念视频

Adrenal Gland Disorders

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...

What is the Endocrine System?

What is the Endocrine System?

The endocrine system sends hormones—chemical signals—through the bloodstream to target cells—the cells the hormones selectively affect. These signals are produced in endocrine cells, secreted into the extracellular fluid, and then diffuse into the blood. Eventually, they diffuse out of the blood and bind to target cells which have specialized receptors to recognize the hormones.

Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

Pathophysiology of Diabetes

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...

Smooth Endoplasmic Reticulum

Smooth Endoplasmic Reticulum

Smooth endoplasmic reticulum or smooth ER is a sub-organelle with specialized functions in animal cells and plant cells. It is often associated with the tubule morphology of the endoplasmic reticulum.
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...

The Endocrine System

The Endocrine System

The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that...