异常的真菌病是由非马尔尼菲Talaromyces在免疫能力强的宿主中引起的
Eun Jeong Won1, Jina Lee2, Jae Suk Baek2
1Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
ASM case reports
|November 17, 2025
概括
这项研究报告了第一个由Talaromyces tumuli引起的真菌病例,该病例发生在一个有中央静脉导管的患者身上. 尽管进行了抗真菌治疗,但感染仍然存在,这凸显了管理Talaromyces tumuli血流感染的挑战.
科学领域:
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
背景情况:
- 塔拉罗米塞斯是一种与Penicillium相关的真菌属,通常是性.
- 塔拉罗米切斯马尔内菲 (Talaromyces marneffei) 是一个例外,已知会引起系统性感染.
- 塔拉罗米塞斯 (Talaromyces tumuli) 被确定为一种罕见的真菌病.
研究的目的:
- 为了记录第一个由Talaromyces tumuli引起的真菌病例.
- 为了描述Talaromyces tumuli fungemia的临床表现和诊断挑战.
- 报告与中央静脉导管相关的Talaromyces tumuli真菌病的治疗方法和结果.
主要方法:
- 进行了血液培养,包括来自中央静脉导管的血液培养.
- 菌的鉴定涉及到MALDI Biotyper sirius系统和基因测序 (ITS,BenA,CaM,RPB2) 的研究.
- 监测了抗真菌敏感性测试和治疗反应.
主要成果:
- 塔拉罗米切斯 (Talaromyces tumuli) 被确定为真菌病的致病原体.
- 感染与中央静脉导管和复发性细菌血症有关.
- 在有氧血培养瓶中观察到真菌生长,检测时间延迟.
- 隔离物显示出类似Penicillium的基体,并且没有产生红色素.
- 进行了沃里康纳治疗,但真菌病持续到导管切除.
结论:
- 这是第一个报告的由Talaromyces tumuli引起的真菌病例.
- 塔拉罗米切斯 (Talaromyces tumuli) 可以导致中静脉导管相关的血液感染.
- 治疗Talaromyces tumuli真菌病可能需要取出导管并进行长时间的抗真菌治疗.
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