由于持续的SARS-CoV-2感染导致的耐药性肺炎在免疫功能低下的宿主中成功地用延长疗程的尼马特里尔维尔/里托纳维尔治疗
Shiro Sonoda1, Sho Shimada1, Atsushi Sawada1
1Department of Respiratory Medicine, Institute of Science Tokyo, Tokyo, Japan.
ASM case reports
|November 17, 2025
概括
在免疫功能低下的患者中,持续的SARS-CoV-2感染可能导致治疗耐药性. 本案例研究显示,一个患有卵泡淋巴瘤的患者在尼马特里尔维尔/里托纳维尔治疗后从长期的XBB变体感染中恢复过来.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 免疫功能低下的人容易患上持续严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染.
- 这些感染往往对标准抗病毒疗法具有耐药性.
研究的目的:
- 在免疫功能低下的患者中报告持续的SARS-CoV-2感染病例.
- 为了研究长期感染期间的病毒演变.
- 评估持续性SARS-CoV-2的治疗结果.
主要方法:
- 一个56岁患有毛囊淋巴瘤的妇女接受化疗的病例报告.
- 在5个月内监测SARS-CoV-2 PCR周期值.
- 病毒基因组测序以识别SARS-CoV-2变种.
- 对雷梅西维尔,葡萄糖皮质类药物和涅马特里尔维尔/里托纳维尔的治疗反应的评估.
主要成果:
- 该患者出现了复发性肺透和持续的SARS-CoV-2感染.
- 尽管初步治疗,她的病情进展到呼吸衰竭.
- 病毒基因组分析显示,从XBB转变为XBB.2.3变异,并累积突变.
- 在20天的涅马特雷尔维尔/里托纳维尔疗程后,患者完全康复.
结论:
- 持续的SARS-CoV-2感染可能导致病毒进化和基因组突变.
- 尼尔马特里尔维尔/里托纳维尔在免疫功能低下的患者治疗持久性SARS-CoV-2感染方面表现出有效性.
- 这一案例凸显了分子监测的重要性,以及针对持久性病毒感染的免疫功能低下个体的量身定制治疗策略.
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