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开发一种适用于药物释放的混合NIR-II温度计
Sonali Mohanty1,2, Mirijam Lederer1, Jorge García-Balduz3
1NanoSensing Group, Department of Chemistry, Ghent University, Krijgslaan 281-S3, Ghent 9000, Belgium.
ACS omega
|November 17, 2025
概括
这项研究引入了一种新的混合温度计,用于在近红外II (NIR-II) 生物窗口中精确的温度传感和深层组织成像. 开发的纳米粒子显示了结合癌症诊断和药物输送应用的潜力.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
背景情况:
- 准确的温度监测对于诊断癌症和炎症等疾病至关重要,因为局部热变化是关键指标.
- 第二个生物窗口 (NIR-II,1000-1700nm) 对于深层组织成像是有利的,因为它减少了生物组织的光散射和吸收.
- (Nd3+) 和 (Yb3+) 合材料在808nm激发下提供高效的能量传输,产生NIR-II范围内的排放.
研究的目的:
- 在NIR-II生物窗口内开发一种新的混合温度计,用于温度传感和成像.
- 为了研究这些混合温度计的潜力,用于theranostic应用,包括药物输送.
主要方法:
- 使用芯和周期性半孔有机 (PMO) 制造混合温度计.
- 用LiLuF4:Nd3+,Yb3+纳米粒子装饰PMO外,用于基于发光的温度传感.
- 用 doxorubicin 装载混合纳米结构来评估药物释放能力.
主要成果:
- 混合温度计成功启用了NIR-II光谱区域的温度传感和成像.
- 该材料表现出高效的发光特性,适合深层组织透.
- 混合纳米结构显示了潜在的可控药物释放,当装载着多克索鲁比.
结论:
- 开发的混合温度计为NIR-II窗口中的非侵入性温度监测和深层组织成像提供了一个有前途的平台.
- 这些发现突显了Nd3+-Yb3+系统在混合纳米结构中的潜力,用于治疗应用,将诊断与向治疗相结合.
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