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Updated: Jan 11, 2026

CRISPR/Cas9-mediated Targeted Integration In Vivo Using a Homology-mediated End Joining-based Strategy
08:22

CRISPR/Cas9-mediated Targeted Integration In Vivo Using a Homology-mediated End Joining-based Strategy

Published on: March 12, 2018

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克里斯普尔-Cas9 HDR优化:RAD52,变质和5'-修饰的DNA模板在敲入小鼠的世代

Boris V Skryabin1, Daniela A Braun2, Helena Kaiser1

  • 1Medical Faculty, Core Facility Transgenic Animal and Genetic Engineering Models (TRAM), University of Muenster, Münster, Germany.

iScience
|November 17, 2025
PubMed
概括

提高动物模型的CRISPR-Cas9基因组编辑效率至关重要. 修改DNA捐赠者模板,特别是在他们的5岁时.

关键词:
生物科学 生物科学基因工程是基因工程,是基因工程.分子遗传学分子遗传学

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