边缘区域B细胞和过功能的明显缺陷在长期ART的HIV-1感染者中表现为缺血
Ségolène Debiesse1, Anne-Sophie Bedin1, Amandine Pisoni2
1Pathogenesis and Control of Chronic Infections, University of Montpellier, INSERM, Etablissement Français du Sang, Montpellier, France.
Open forum infectious diseases
|November 17, 2025
概括
艾滋病毒感染者往往会出现脏功能受损,影响免疫反应. 这项研究发现,长期接受抗逆转录病毒治疗的个体的边缘区域B细胞减少和过问题,突出显示了持续的脏损伤.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 血液学 血液学 血液学
背景情况:
- 艾滋病毒感染者 (PWH) 面临更高的肺炎球菌疾病的风险.
- 这项研究研究了长期抗逆转录病毒疗法 (ART) 的PWH中脏过和免疫功能.
- 在这群人群中,研究了低度的预测因素.
研究的目的:
- 开发和验证用于评估脏功能的流细胞计方案.
- 为了研究脏损伤,特别是Howell-Jolly体 (HJBs) 和边缘区域B细胞 (MZBs),在长期ART的PWH中.
- 为了确定PWH.中潜在的hyposplenism预测因素.
主要方法:
- 建立了一个流细胞计量协议来量化HJBs和MZBs.
- 该协议通过比较脊髓切除术患者和健康捐赠者的结果来验证.
- 一项横截面研究分析了长期ART的96个PWH中的HJB和MZB.
主要成果:
- 确定了HJBs (0.05%) 和MZBs (10%) 的最佳切割值,以区分脏功能.
- 结果与评估脏过的既定方法相关.
- 在接受ART的PWH中,9.4%的患者表现出脏过功能受损 (HJBs升高),与艾滋病病史有关. 59.4%的MZBs下降,与HJBs没有相关性.
结论:
- 长期接受ART的PWH表现出脏边缘区域B细胞减少,一些人显示脏过功能受损.
- 这些发现表明,尽管病毒被抑制,但脏功能持续受损.
- 需要进一步的研究,以了解艾滋病毒对脏功能的长期影响,并改善老化PWH的结果.
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