时间限制的低热量饮食在与代谢功能障碍相关的性肝病患者中比单独的低热量饮食更能提高胰岛素敏感性:一项随机对照试验
Shaiphali Sharma1, Sandeep Bhattacharya1, Shraddha Singh1
1Department of Physiology, King George Medical College Lucknow, India.
Journal of clinical and experimental hepatology
|November 17, 2025
概括
时间限制饮食 (TRE) 在患有代谢功能障碍相关脂肪肝炎 (MASLD) 的个体中显著改善了胰岛素耐药性. 这种饮食方法在12周内显示出比单纯的低热量饮食更大的益处.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 胰岛素耐药性是代谢功能障碍相关的脂肪肝炎 (MASLD) 病原体的核心.
- 时间限制饮食 (TRE) 在提高对代谢障碍的胰岛素敏感性方面表现有前途.
研究的目的:
- 评估TRE对MASLD患者胰岛素耐药性的影响.
- 为了评估TRE的代谢概况和肝肥胖症的变化.
主要方法:
- 患有MASLD的成年人 (18-60岁) 被随机分为两组:TRE与低热量饮食 (TRE + HCD) 或单独的低热量饮食 (HCD).
- 主要终点是12周内对胰岛素耐药性 (HOMA-IR) 均静态模型评估的变化.
- 二级终点:肝硬化等级的改善.
主要成果:
- 与HCD组 (1.55 ± 1.2) (P=0.024) 相比,TRE + HCD组显示HOMA-IR (2.6 ± 1.9) 的平均减少显著更大.
- 在TRE+HCD组中,较高比例的参与者 (66.7%) 与HCD组相比 (52.4%) 实现了1度的肥胖症改善,尽管这在统计学上并不显著 (P=0.26).
结论:
- 与低热量饮食相结合的时间限制饮食为MASLD患者提供了与单独低热量饮食相比,对胰岛素抵抗的卓越改善.
- TRE显示出作为治疗策略的潜力,用于管理MASLD患者的胰岛素抵抗.
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