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Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
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Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
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相关实验视频

Updated: Jan 11, 2026

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功能激活的改变与多发性硬化症患者的语言功能障碍有关.

Katherine Hope Kenyon1, Frederique Boonstra1, Gustavo Noffs1

  • 1Monash University, Melbourne, Victoria, Australia.

Neurobiology of language (Cambridge, Mass.)
|November 17, 2025
PubMed
概括

患有多发性硬化症 (pwMS) 的人在说话时显示出大脑激活的改变. 患有脱节性关节炎和震的人减少了补偿性大脑活动,表明疾病更为晚期和管理选择有限.

关键词:
脱节性关节障碍症 脱节性关节障碍症是一种疾病.多发性硬化症多发性硬化症神经成像是一种神经成像.神经语言学是神经语言学.演讲制作 演讲制作 演讲制作

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科学领域:

  • 神经科学是一个神经科学.
  • 神经学 神经学
  • 语音语言病理学 语言病理学

背景情况:

  • 发病症是多发性硬化症 (MS) 中常见的运动语言障碍,通常与小脑功能障碍有关.
  • 了解MS相关性脱节性关节炎的脑功能变化是有限的,阻碍了有效的管理策略.

研究的目的:

  • 为了研究多发性硬化症 (pwMS) 患者的语音产生过程中的功能性大脑激活变化.
  • 为了比较pwMS的激活模式,有或没有失联症和/或小脑功能障碍 (动作震).

主要方法:

  • 功能磁共振成像 (fMRI) 用于评估语音任务期间的大脑活动.
  • 55名pwMS和14名健康对照参与了这项研究,MS参与者被分类为缺动性关节炎和动作的存在.

主要成果:

  • 与对照人群相比, pwMS 在语音准备过程中表现出较差的语音表现和降低的整体功能激活.
  • 在语音制作过程中,pwMS显示左边Brodmann区域45和46的招募增加.
  • 患有脱关节障碍和动作震的参与者表现最差,功能激活率较低,这表明晚期多发性多发性硬化症的补偿机制减少.

结论:

  • 多发性硬化症导致运动语言区域的功能激活发生变化.
  • 补偿激活在pwMS中减少,既有脱发性关节炎和动作震,可能是由于疾病进展.
  • 需要进一步的研究,以制定针对性管理策略pwMSdysarthria.