功能激活的改变与多发性硬化症患者的语言功能障碍有关
Katherine Hope Kenyon1, Frederique Boonstra1, Gustavo Noffs1
1Monash University, Melbourne, Victoria, Australia.
Neurobiology of language (Cambridge, Mass.)
|November 17, 2025
概括
患有多发性硬化症 (pwMS) 的人在说话时显示出大脑激活的改变. 患有脱节性关节炎和震的人减少了补偿性大脑活动,表明疾病更为晚期和管理选择有限.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 语音语言病理学 语言病理学
背景情况:
- 发病症是多发性硬化症 (MS) 中常见的运动语言障碍,通常与小脑功能障碍有关.
- 了解MS相关性脱节性关节炎的脑功能变化是有限的,阻碍了有效的管理策略.
研究的目的:
- 为了研究多发性硬化症 (pwMS) 患者的语音产生过程中的功能性大脑激活变化.
- 为了比较pwMS的激活模式,有或没有失联症和/或小脑功能障碍 (动作震).
主要方法:
- 功能磁共振成像 (fMRI) 用于评估语音任务期间的大脑活动.
- 55名pwMS和14名健康对照参与了这项研究,MS参与者被分类为缺动性关节炎和动作的存在.
主要成果:
- 与对照人群相比, pwMS 在语音准备过程中表现出较差的语音表现和降低的整体功能激活.
- 在语音制作过程中,pwMS显示左边Brodmann区域45和46的招募增加.
- 患有脱关节障碍和动作震的参与者表现最差,功能激活率较低,这表明晚期多发性多发性硬化症的补偿机制减少.
结论:
- 多发性硬化症导致运动语言区域的功能激活发生变化.
- 补偿激活在pwMS中减少,既有脱发性关节炎和动作震,可能是由于疾病进展.
- 需要进一步的研究,以制定针对性管理策略pwMSdysarthria.
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