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Updated: Jan 11, 2026

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设计,合成和结构-活性关系分析二二二松衍生物对抗Osimertinib耐药的NSCLC

Chengliu Jin1, Zhen Zhang1, Peng Liao1

  • 1School of Chemistry and Chemical Engineering, Guangdong Cosmetics Engineering & Technology Research Center, Guangdong Pharmaceutical University Zhongshan 528458 P. R. China.

RSC medicinal chemistry
|November 17, 2025
PubMed
概括

新的双二氨化合物显示出对EGFR突变的非小细胞肺癌 (NSCLC) 的承诺. 化合物33有效地准了对 osimertinib 耐药的细胞,提供了潜在的新治疗策略.

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Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
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Cholinergic agonists or cholinomimetics mimic the action of acetylcholine to stimulate the parasympathetic nervous system. They are categorized into direct-acting and indirect-acting agents. The direct-acting cholinergic drugs induce the parasympathetic response by directly binding to the muscarinic or nicotine receptors. In comparison, the indirect-acting cholinergic drugs prevent acetylcholine hydrolysis, indirectly contributing to the extended parasympathetic response.
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Cholinergic antagonists bind to cholinergic receptors and limit the effects of acetylcholine and other cholinergic agonists. Based on the specific cholinergic receptor affinity, these antagonists are classified as muscarinic or nicotinic. Anticholinergics interrupt parasympathetic innervations while sympathetic innervations remain uninterrupted. Muscarinic antagonists are also called 'muscarinic antagonists', 'antimuscarinics', or 'parasympatholytics'. Nicotinic...
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