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生物标志物分类系统在移植与宿主疾病中的现状,挑战和整合途径:初步探索

Xinxin Yu¹, Shuai Huang¹, Xiaoxia Li²

¹School of Clinical Medicine, Shandong Second Medical University, Weifang, China.

Frontiers in medicine

|November 17, 2025

概括

一个新的框架根据机制,应用和分子特征对移植与宿主疾病 (GVHD) 生物标志物进行了分类. 这种系统的方法有助于数据集成和精确医学用于GVHD管理.

科学领域:

生物医学科学生物医学科学
免疫学免疫学免疫学
移植医学移植医学

背景情况:

移植与宿主疾病 (GVHD) 是全源造血干细胞移植的一个关键并发症.
目前的GVHD生物标志物分类系统是分散的,阻碍了数据集成和临床翻译.
迫切需要对GVHD生物标志物的系统分类框架.

研究的目的:

系统地评估GVHD生物标志物的现有分类系统.
为GVHD生物标志物提出一个新的三维分类框架.
为推进GVHD管理中的精准医学提供基础结构.

主要方法:

使用PubMed和科学网络 (2012-2025) 的系统文献综述.
关键词:"GVHD"",生物标志物"",分类和总结".
包括139篇专家评审的文章,重点关注GVHD生物标志物分类或临床应用.

主要成果:

将GVHD生物标志物整合到一个三维系统中:病理生理机制,临床应用场景和分子特征.
确定GVHD生物标志物研究和应用中的关键挑战.
为GVHD生物标志物数据提供可行的整合途径的建议.

结论:

拟议的框架提供了一个系统的方法来分类GVHD生物标志物.
这种分类有助于跨研究数据的整合和临床翻译.
该框架支持开发针对GVHD的精准医学策略.

关键词:

全源性造血干细胞移植造血干细胞移植生物标志物生物标志物分类系统的分类系统.接种与宿主病的疾病.整合途径整合途径精准医学是一门精准医学.

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