由于怀孕期间的抗A抗体而引起的血溶性输血反应:病例报告
Suhalika Sahni1, Katharine Sweeney2, Franklin Njoku3
1Department of Pathology, University of Illinois at Chicago, Chicago, Illinois, USA.
Case reports in immunology
|November 17, 2025
概括
一种罕见的抗A1抗体在患有状细胞病的孕妇患者中引起了严重的输血反应. 这突显了需要在高风险患者中仔细进行血液匹配,以防止延迟的血液溶解输血反应.
科学领域:
- 输血医学 输血医学
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
背景情况:
- 在输血医学中,ABO血型系统至关重要.
- 弱A子组,如A2,可以产生抗A1抗体.
- 这些抗体通常具有冷反应性,但在37°C时可以引起显著的血液溶解.
研究的目的:
- 在患有状细胞疾病的孕妇患者中报告严重延迟血解输血反应 (DHTR) 的病例.
- 突出针对特定患者群体的抗A1抗体的临床意义.
- 强调输血警在状细胞病中的重要性.
主要方法:
- 一个孕妇患有状细胞病和高血解综合征的病例报告.
- 输血A1红细胞 (红细胞).
- 输血后对抗A1抗体的鉴定.
主要成果:
- 患者在接受A1红细胞后出现严重的DHTR.
- 检测到抗A1抗体,证实非A1亚型.
- 该患者在O组RBC输血后也经历了血液溶解,这表明血液溶解过高.
结论:
- 抗A1抗体可以导致临床显著的DHTR,特别是在高风险患者中.
- 状细胞病患者有过高血解史,需要加强输血管理.
- 仔细选择血液成分对于预防脆弱人群的输血并发症至关重要.
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