治疗慢性支气管炎的药用植物和化合物:疗效和作用机制
Wei Ding1, Danni Chen1, Jiawang Li1
1College of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
药用植物和化合物通过减少炎症和粘液显示出治疗慢性支气管炎 (CB) 的前景. 乌尔索酸是关键候选物,天然剂为新药开发提供了潜力.
科学领域:
- 肺部病理学 肺部病理学
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
背景情况:
- 慢性支气管炎 (CB) 是一种复杂的肺部疾病,具有持续的炎症,氧化应激和粘液过度产生.
- 目前对CB的治疗方法不足,这凸显了需要新的治疗方法的需要.
- 药用植物及其化合物被认为具有治疗炎症性肺部疾病的潜力.
研究的目的:
- 系统地审查药用植物和化合物的疗效和分子机制,以治疗慢性支气管炎 (CB).
- 识别与CB相关的具有多目标治疗效果的天然产品.
- 巩固证据支持使用自然剂用于CB管理.
主要方法:
- 根据一个注册的协议 (PROSPERO ID:CRD42024588912) 进行了系统审查.
- 在多个电子数据库 (PubMed,Scopus,Embase,Web of Science,VIP,Wan-fang,SinoMed,CNKI) 进行了全面的文献搜索.
- 研究选择遵循PICOS原则,以确定CB的相关药用植物和化合物.
主要成果:
- 13种药用植物和19种化合物表现出抗炎活性.
- 8种植物和12种化合物表现出抗氧化剂,抗粘液和支气管扩张作用.
- 关键的分子通路包括NF-κB,PI3K/AKT/mTOR,TLR4,MAPK和Nrf2;乌尔索酸被确定为一个有前途的候选人.
结论:
- 本综述提供了药用植物和化合物对CB的疗效和机制的全面综合.
- 临床前研究证实了这些天然剂在缓解CB症状方面的治疗益处.
- 自然产品为开发治疗慢性支气管炎的新药提供了重要的翻译潜力.
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