单核酸多形态与癌症免疫疗法的疗效和毒性之间的关系:系统性审查
Monia Specchia1,2, Marco Siringo1,3, Eva Mazzotti1
1Oncology Unit, Sant'Andrea University Hospital, Rome, Italy.
Frontiers in oncology
|November 17, 2025
概括
像CTLA-4,PD-1和PD-L1这样的免疫检查点基因中的单核酸多态 (SNP) 可以预测患者对癌症免疫疗法的反应和毒性,帮助个性化治疗策略.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
背景情况:
- 免疫疗法,特别是免疫检查点抑制剂 (ICI),已经改变了癌症护理.
- 然而,预测患者的反应和不良事件仍然是一个挑战.
- 识别预测生物标志物对于优化ICI治疗至关重要.
研究的目的:
- 系统地审查单核酸多态性 (SNP) 在调节免疫检查点的基因中的作用.
- 评估这些SNP对癌症免疫治疗结果和毒性的影响.
主要方法:
- 在PubMed和Cochrane数据库 (2000-2024) 中进行了全面的文献搜索.
- 选了884件作品,其中29项研究被纳入最终分析.
- 该审查重点关注CTLA-4,PD-1和PD-L1基因中的SNP及其与ICI疗效和毒性的关联.
主要成果:
- 发现CTLA-4,PD-1和PD-L1基因中的特定SNP会影响免疫治疗反应和与免疫相关的不良事件.
- 某些CTLA-4和PD-1SNP与改善生存率或增加毒性相关.
- PD-L1 SNPs显示对瘤对ICI的反应产生影响,这表明它们有可能作为预测性生物标志物.
结论:
- 免疫检查点基因中的SNP是癌症免疫疗法的有效性和安全性的重要决定因素.
- 这些遗传变异有望成为个性化癌症治疗的预测生物标志物.
- 需要进一步的研究来验证这些发现,并将其纳入临床实践.
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