dbGVOSCC:一个全面的基因变异数据库,用于系统遗传学研究口腔状细胞癌的研究
Yi Zhou1, Yutao Wu1,2, Wenjing Shi1,3
1Department of Breast Surgery and Institute for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.
Frontiers in oncology
|November 17, 2025
概括
一个新的数据库,dbGVOSCC,列出了口腔状细胞癌 (OSCC) 的遗传变异. 这个资源有助于研究OSCCCC的研究.
科学领域:
- 基因组学和生物信息学
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 口腔状细胞癌 (OSCC) 是一种具有高转移率和对生活质量显著影响的侵袭性恶性瘤.
- 目前对于OSCC没有常规查计划,强调需要更好地了解其遗传基础.
- 遗传异质性有助于OSCC的复杂性,需要全面的数据资源.
研究的目的:
- 开发和展示口腔状细胞癌 (dbGVOSCC) 的遗传变异数据库.
- 为OSCC中遗传变异数据提供一个集中的,精心策划的资源.
- 促进基因型-表型关联研究和系统遗传学研究在OSCC.
主要方法:
- 来自PubMed的OSCC研究 (1991-2024) 的文献搜索,手动选和通过PubTator.
- 在浏览器/服务器架构 (HTML,XAMPP,Apache,MySQL,PHP/JavaScript) 中组织的基因变异实体和关系的提取.
- 生物信息分析包括将基因映射到STRING,枢纽基因识别 (PPI中心度) 和GO/KEGG丰富分析.
主要成果:
- dbGVOSCC包含来自400项研究和106,079个临床样本的1,788个体质遗传变异条目.
- 数据库包括各种突变类型 (表皮突变,SNP,indels,CNV,LOH) 和817个生物标志物相关的变异 (诊断,治疗,预后).
- 确定了关键基因 (例如TP53,CTNNB1,AKT1),丰富分析表明扩散,粘附/迁移以及PI3K-Akt信号通路.
结论:
- dbGVOSCC是关于口腔状细胞癌遗传变异的强大可靠的知识库.
- 该数据库作为个性化基因型-表型关联研究的开源平台.
- dbGVOSCC支持系统遗传学研究推动OSCC发展和进步的机制.
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