维普尔病的运动障碍和眼运动异常:最新的系统性审查
Errikos Maslias1, Ruben Anker2, Philip Euskirchen3,4
1Service of Neurology, Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.
Tremor and other hyperkinetic movements (New York, N.Y.)
|November 17, 2025
概括
运动障碍和眼运动异常是中枢神经系统惠普尔病 (CNS-WhD) 的关键指标. 早期识别这些症状,特别是超核视力麻和肌律失常,可以改善这种可治疗的感染的结果.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 眼科医生 眼科 眼科
背景情况:
- 惠普尔病 (WhD) 是一种罕见的多系统性感染,由*Tropheryma whipplei*引起.
- 中枢神经系统 (CNS) 的参与发生在高达50%的WhD病例中,经常呈现神经症状.
- 运动障碍 (MDs) 和眼运动异常,如眼肌节律 (OMM) 和眼面骨肌节律 (OFSM),是关键的诊断线索,但往往被忽视.
研究的目的:
- 更新对中枢神经系统-白血病中MD的理解.
- 通过结合最近的案例数据,在以前的审查基础上构建.
- 突出特定神经和眼运动症状的诊断重要性.
主要方法:
- 在MEDLINE,EMBASE和Cochrane图书馆的系统文献搜索 (01/2017-05/2025).
- 包括英语语言的人类研究.
- 标题,摘要和全文的选由两个独立的评论员使用Rayyan.ai.
主要成果:
- 增加了19篇新文章 (22例),总共有168名中枢神经系统-白血病患者患有MD或眼运动异常.
- 超核视力麻 (SGP) 是最常见的症状 (58%),其次是肌节律失常和心动失常 (40%分别).
- 病理性OMM/OFSM发生在25%的病例中. 在87%的患者中发现了MRI异常,脑组织PAS染色显示出高的诊断产量.
结论:
- 眼运动异常和MDs,特别是SGP和肌律失常,是中枢神经系统-WhD的关键诊断指标.
- 即使没有全身症状,这些迹象也很重要.
- 提高诊断意识对于改善这种危及生命但仍可治疗的疾病的结果至关重要.
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