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牛奶蛋白质过敏与失去蛋白质的肠道病变在范围内的范围
Morgane Thorens-Borgeat1, Géraldine Blanchard-Rohner2, Salim Ramadan3
1Pediatric Gastroenterology, Hepatology and Nutrition Unit, Geneva University Hospitals, Department of Pediatrics, Gynecology, and Obstetrics University of Geneva Geneva Switzerland.
JPGN reports
|November 17, 2025
概括
牛奶蛋白过敏 (CMPA) 可以导致婴儿严重的蛋白质丧失肠道病变 (PLE). 整个胃肠道的组织学发现有所不同,这突显了诊断这种疾病的复杂性.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 过敏 免疫学 免疫学
- 胃肠道病理 胃肠道病理
背景情况:
- 牛奶蛋白过敏 (CMPA) 是婴儿常见的疾病.
- 严重的CMPA可以导致蛋白质丧失肠病 (PLE),带来诊断挑战.
- 在CMPA中PLE的潜在机制尚未完全理解.
研究的目的:
- 报告四例严重的CMPA与PLE需要内镜评估的病例.
- 描述CMPA诱导的PLE在胃肠道沿线的变异性组织学表现.
主要方法:
- 四个婴儿患有严重的CMPA和PLE的案例系列.
- 进行内镜检查,排除其他肠道病变.
- 胃肠道活检的组织病理学检查.
主要成果:
- 所有患者在胃肠道活检中都表现出埃索诺菲利亚.
- 组织学显示出显著的变异性,包括严重的粘膜缩和结肠腺损失.
- 在内镜检查结果和组织学结果之间观察到的相关性很差.
结论:
- CMPA可以影响消化道的任何部位,并具有不同的组织学表现.
- 婴儿和儿童的低albuminemia可能表明食物蛋白质过敏.
- 内镜和组织学评估对于诊断严重的CMPA相关PLE至关重要.
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