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药物诱导的肝损伤与选择性雄激素受体调节剂相关,在一个青少年患者

David J Katibian^1,2, Laura E Bauman^1,2, Katayoon Shayan^3,4

¹Department of Pediatrics University of California, La Jolla San Diego California USA.

|November 17, 2025

概括

选择性雄激素受体调节剂 (SARMs) 可以导致青少年的肝损伤,呈现与成人不同. 这一案例凸显了SARM在健美补充剂中的各种风险.

科学领域:

药理学药理学是指药理学的学科.
肝病学肝病学是一种肝病学.
毒理学毒理学毒理学

背景情况:

选择性雄激素受体调节剂 (SARMs) 是研究肌肉和骨生长的化合物,模仿具有组织特异性雄激素受体结合的类固醇.
虽然SARM具有潜在的益处,但由于越来越多的肝毒性报告,特别是使用健美补充剂的成年人,人们对其安全性产生了担忧.

研究的目的:

报告第一个已知的SARMs相关的青少年肝损伤病例.
为了突出青少年与成年人相比,肝损伤的独特模式.
为了强调基于化合物类型和剂量的SARMs诱导的肝损伤的变化.

主要方法:

一个青少年出现肝损伤的案例报告.
肝损伤模式的临床和组织学评估.
对有关SARM相关肝毒性现有文献的综述.

主要成果:

青少年患者表现出主要是肝细胞损伤的肝损伤模式.
这与之前报告的成年病例形成鲜明对比,这些病例主要显示出胆固醇损伤模式.
这些发现表明,SARM诱导的肝损伤模式可能因特定的SARM和消耗量等因素而异.

结论:

与SARM相关的肝损伤可能发生在青少年中,并且可能与成人不同的组织学模式呈现.
这一案例强调了需要提高人们对SARM可能造成的肝损伤的认识,尤其是在补充剂使用的背景下.
需要进一步的研究,以充分阐明SARM诱导的肝毒性风险和差异在不同人群和暴露水平之间.

关键词:

这就是SARMs.肝毒性肝毒性肝毒性补充剂补充剂补充剂

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