婴儿早期的肠道捐赠者:免疫介导的并发症更有问题吗?
Angus Hann1,2,3, Girish Gupte1, Jane Hartley1
1Liver and Intestinal Transplant Unit, Birmingham Children's Hospital, Birmingham, United Kingdom.
Transplantation direct
|November 17, 2025
概括
来自6个月以下的婴儿进行肠移植的移植与严重的免疫性并发症的更高率有关,包括排斥和移植对宿主疾病. 这些并发症导致了这一早期婴儿组中很大一部分接受者的死亡.
科学领域:
- 儿科外科手术 儿科外科手术
- 移植免疫学 移植免疫学
- 胃肠病学 胃肠病学
背景情况:
- 儿科肠道移植面临着供体大小的限制.
- 来自非常年轻的捐赠者 (≤6个月) 的移植是一种选择,但缺乏关于免疫结果的数据.
- 这项研究解决了关于接受肠子移植的婴儿移植后免疫学并发症的文献稀缺问题.
研究的目的:
- 评估来自非常年轻 (≤6个月) 捐赠者的含肠子移植的结果.
- 为了比较不同婴儿捐赠者年龄组的免疫学并发症.
- 为了告知临床实践关于婴儿肠移植的使用.
主要方法:
- 儿科肠道移植 (1993-2020) 的回顾性单中心研究.
- 参与者分为早期婴儿 (EI, ≤6个月),晚期婴儿 (LI, 7-12个月) 和早期儿童 (EC, 13-36个月) 捐赠组.
- 主要结局:临床显著的免疫学并发症 (严重的排斥/移植对宿主疾病).
主要成果:
- 在105例儿科肠道移植中,有35例使用了≤36个月的捐赠者.
- 免疫学并发症在EI组中最常见 (80%),其次是LI (56%) 和EC (33%).
- 在EI组的五名接受者中,有三名因免疫学并发症而死亡.
结论:
- 在生命的前6个月内从捐赠者的移植与免疫学并发症的增加有关.
- 建议在使用6个月或更年轻的捐赠者肠道移植时谨慎使用.
- 可能需要进一步的研究,以减轻与早期婴儿肠移植相关的风险.
相关概念视频
Immunodeficiency Diseases
1.9K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
1.9K
Development of Immunocompetence
778
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
778
Bone Marrow Sampling and Transplants
846
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
846
Cell-mediated Immune Responses
83.4K
Overview
83.4K
Inflammatory Bowel Disease I: Ulcerative Colitis
880
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
880
Tissue Transplantation
883
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
883


