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诱导热和重编程巨细胞通过化石的imidazolate框架封装-富勒伦为双端瘤免疫疗法

Zihao Sun^1,2, Lei Liu^1,2, Jiacheng Sun^1,2

¹Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.

Bioactive materials

|November 17, 2025

概括

这项研究引入了一种新型的双功能纳米疗法,使用氨酸修饰的化物伊米达酸框架-8和C70富勒烯. 这种方法增强了瘤免疫性,并重新编程瘤微环境,以改善癌症治疗.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
免疫治疗是一种免疫疗法.

背景情况:

感冒瘤具有较低的免疫性和免疫抑制性瘤微环境 (TME),阻碍了有效的癌症治疗.
克服这些障碍对于开发有效的免疫疗法至关重要.

研究的目的:

开发一种双功能纳米疗法,以增强瘤免疫性,并重新编程TME以改善癌症治疗.
为了研究氨酸修饰的化物伊米达酸框架-8和C70富勒伦 (HA-C70@ZIF-8) 纳米复合物的有效性.

主要方法:

HA-C70@ZIF-8纳米复合材料被设计用于CD44向和选择性瘤吸收.
内化触发了Zn2+的释放,诱导了热和DAMPs的释放.
封装的C70重编程瘤相关巨细胞 (TAMs) 从M2变为M1表型.

主要成果:

HA-C70@ZIF-8通过HA介导的CD44相互作用证明了选择性瘤向和保留.
Lysosomal 条件诱导了 pyroptotic 细胞死亡和损伤相关分子模式 (DAMPs) 的释放.
重编程TAM减轻了瘤免疫抑制,增强了免疫反应.

结论:

双功能纳米疗法有效增强瘤免疫性,并重新编程TME.
这一策略增强了免疫检查点封锁的有效性,为个性化瘤治疗和免疫治疗提供了有前途的方法.

关键词:

富勒利尼是一种富勒利尼.免疫治疗是一种免疫疗法.热灭菌的发生.与瘤相关的巨细胞.泽奥利特性意达酸框架-8-8

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Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.