大脑连接缓和了认知内个体可变性对认知脆弱的老年人移动性的影响
Jingyi Wu1, Jinyu Chen1, Juncen Wu1
1Department of Rehabilitation Sciences, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong, Hong Kong SAR, China.
Frontiers in aging neuroscience
|November 17, 2025
概括
认知虚弱增加了认知变性 (IIV) 并改变了大脑网络连接. 特定的大脑网络的变化可能会保护认知虚弱的老年人的运动能力.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 认知科学 认知科学
背景情况:
- 认知障碍是一种轻度认知障碍和身体障碍的组合,会造成严重的健康风险.
- 认知个体内变异性 (IIV) 表明早期的认知和运动能力下降.
- 了解IIV在认知虚弱中的神经基础对于有针对性的干预至关重要.
研究的目的:
- 研究大脑网络功能连接,IIV和老年人的移动性之间的关联.
- 探索在认知脆弱个体中增加IIV的基础的神经机制.
主要方法:
- 这项研究包括38名社区老年人 (17人有认知障碍,21人没有认知障碍).
- 评估包括认知测试 (Trail Making Test,Stroop Test),运动测试 (Timed Up and Go) 和休息状态fMRI.
- IIV被量化为跨执行测试的分散 (IIV-分散);功能网络连接性被分析.
主要成果:
- 与非认知脆弱的个体相比,认知脆弱的个体显示出更大的IIV分散.
- 在感觉运动网络 (SMN) 内以及默认模式网络 (DMN),前端执行网络 (FEN) 和认知脆弱组的SMN之间观察到减少的连接性.
- DMN-FEN连接调节了IIV分散和移动性 (TUG性能) 之间的关系,表明它具有保护作用.
结论:
- 经过大规模大脑网络的功能连接的改变可能是认知脆弱性IIV增加的基础.
- 局部的DMN-FEN连接性重新配置可能代表了补偿机制,保护移动性免受IIV对认知脆弱的影响.
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