基因变异的空间和时间模式与野生白尾鹿对慢性浪费疾病诱导的选择的反应一致
Christine M Bubac1,2, Ty Russell2, Debbie McKenzie2
1Department of Biology Carleton University Ottawa Ontario Canada.
Ecology and evolution
|November 17, 2025
概括
蛋白基因 (PRNP) 的遗传变异可能会提供对慢性衰竭疾病 (CWD) 的弹性. 白尾鹿的一种特定的PRNP变体 (G96S) 与CWD耐药性有关,其频率随着时间和空间的变化而增加.
科学领域:
- 遗传学 是一个遗传学.
- 野生动物疾病生态学 野生动物疾病生态学
- 进化生物学 进化生物学
背景情况:
- 慢性消耗性疾病 (CWD) 是北美各地鹿类种群的重大威胁.
- 假设蛋白基因 (PRNP) 变异会影响对CWD的遗传性.
- 了解PRNP变异对于管理CWD和保护敏感物种至关重要.
研究的目的:
- 调查PRNP基因变异与白尾鹿 (WTD) 和鹿 (MD) 中CWD易感性之间的关联.
- 评估对PRNP等位基因起作用的选择特征,以应对CWD流行.
- 检查假定保护PRNP等位基因的空间和时间动态.
主要方法:
- 在加拿大阿尔伯塔省采集的575个WTD和660个MD样本中测序PRNP基因.
- 在PRNP基因中单核酸多态位点的基因定型.
- 统计分析以将PRNP基因型与CWD状态联系起来,以及对等位基因频率变化的空间/时间分析.
主要成果:
- 在鹿中没有发现PRNP变异与CWD状态之间的关联.
- 在白尾鹿中检测到一个显著的关联,在CWD阳性个体中,96S等位基因 (G96S变体) 代表性不足.
- 96S等位基因的频率随着接近最初的CWD检测点和随着时间的推移而增加,与选择压力一致.
结论:
- 在WTD PRNP基因中的G96S变异似乎赋予了慢性消耗性疾病的某种程度的弹性.
- 在白尾鹿种群中,CWD正在对PRNP等位基频率施加选择压力.
- 这种遗传性可能会影响CWD的长期动态和传播.
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