在COVID-19后12个月出现呼吸系统症状的患者中,胸部计算机断层扫描和肺功能异常之间的关联
Luciano Folador1,2, Vicente Bohrer Brentano1, Ravena Maya Cardoso da Silva2
1Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil.
Radiologia brasileira
|November 17, 2025
概括
许多患有COVID-19后病情的患者在感染后12个月内表现出持续的肺部异常. 这些发现,包括纤维化,与肺功能下降和限制性肺病相关.
科学领域:
- 肺部病理学 肺部病理学
- 放射学 放射学是一门学科.
- 传染性疾病 传染性疾病
背景情况:
- 后COVID-19状态可能导致持续的呼吸道症状.
- COVID-19对肺部结构和功能的长期影响需要彻底调查.
研究的目的:
- 在COVID-19后12个月使用胸部CT和肺功能测试 (PFTs) 来评估残留的肺异常.
- 在这些患者中分析CT发现与PFT参数之间的关联.
主要方法:
- 两个放射科医生对胸部CT扫描进行了分析,以进行半定量得分.
- 肺功能测试包括螺旋测量,囊造影和一氧化碳的扩散能力.
- 包括37名患有与COVID-19后状况相关的呼吸道症状的患者.
主要成果:
- 78.3%的患者在12个月后在CT上表现出剩余的肺部异常.
- 常见的发现包括网膜不透明 (75.7%),引支气管 (43.2%) 和纤维化样变化 (43.2%).
- 纤维化样发现与明显较低的肺总容量 (p=0.018) 和CT得分与肺总容量 (rs=-0.49,p=0.003) 之间的负相关性有关.
结论:
- 在COVID-19后出现呼吸系统症状的患者中,很大一部分在12个月后仍然存在肺部异常.
- 纤维化样发现很普遍,并与限制性肺病相关.
- 胸部CT和PFT对于评估COVID-19的长期肺部后果至关重要.
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