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在耶路撒冷,以色列,聚克隆OXA-244产生大肠杆菌血统的循环

Janko Sattler¹, Yonatan Oster^2,3, Helena M B Seth Smith⁴

¹Department of Machine Learning and Systems Biology, Max Planck Institute of Biochemistry, Martinsried, Germany.

JAC-antimicrobial resistance

|November 17, 2025

概括

在耶路撒冷的医院中,产生OXA-244的大肠杆菌越来越普遍. 这项研究强调了它们在OXA-48类碳酶生产者中的主导地位,这表明它们未被认可的社区传播.

科学领域:

微生物学微生物学
基因组学就是基因组学.
传染性疾病传染性疾病

背景情况:

产生OXA-244的大肠杆菌 (大肠杆菌) 是欧洲的一个新兴威胁.
类似于OXA-48的碳烯酶在2007年在以色列首次被发现.
最近有报道称OXA-244产生大肠杆菌的循环.

研究的目的:

为了确定OXA-244在耶路撒冷一家医院OXA-48类似的生产大肠杆菌中的比例.
为了分析blaOXA-244.4的获取,原生,抗体和遗传背景.

主要方法:

从2024年开始,对53种产生OXA-48类似的大肠杆菌分离体进行全基因组测序 (短读和长读).
分析患者数据以进行传播分类.
核心基因组多位置序列类型化 (MLST) 用于基因组聚类.

主要成果:

在OXA-48类似的生产者中,OXA-244是占主导地位的碳烯酶 (34/53分离物).
大多数OXA-244大肠杆菌与医疗保健相关 (88.2%),但11.8%是社区获得的.
隔离品显示了13种序列类型 (ST) 的克隆多样性,其中blaOXA-244位于Tn51098变体内的染色体上.

结论:

在耶路撒冷的第三级护理医院中,产生OXA-244的大肠杆菌占主导地位.
克隆多样性表明正在进行的,未被检测到的社区传播.
有针对性的监督和控制措施至关重要.

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