军事卫生系统中的Candida auris监测:一种多抗药性威胁
J Joseph Brough1, Graham C Ellis1, Sara L Robinson2
1Walter Reed National Military Medical Center, Bethesda, MD, USA.
Antimicrobial stewardship & healthcare epidemiology : ASHE
|November 17, 2025
概括
在2024年,在美国军事卫生系统中发现了6例多药耐药Candida auris病例. 目前的查策略不足以检测大多数病例,突出需要改进Candida auris监测.
科学领域:
- 传染性疾病 传染性疾病
- 菌类学 菌类学是指菌类学.
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 黄是一种多药耐药的真菌病原体,对全球健康构成重大威胁.
- 美国军事卫生系统 (MHS) 需要了解其对C. auris.的脆弱性.
- 有效的查和监测对于控制C. auris疫情至关重要.
研究的目的:
- 评估MHS. 内的Candida auris的潜在来源.
- 评估目前在MHS中对C. auris的查策略的有效性.
- 发现C. auris监测和控制措施中的差距.
主要方法:
- 利用多药耐药生物存储库和监测网络 (MRSN) 来识别C. auris病例.
- 收集了关于病史,社会史,药物易感性和遗传测序的数据.
- 在发现C. auris病例的设施中审查了医院查协议.
主要成果:
- 在2024年在MHS确定了6例C. auris (1例感染,5例殖民) 的病例.
- 大多数病例缺乏最近的国际旅行史;之前住院是常见的风险因素.
- 两种隔离物体对可纳产生了耐药性;查方案只发现了一个病例.
结论:
- 黄菌对MHS构成重大威胁,已确定对醇的耐药性.
- 目前的查方案不足以有效地检测C. auris病例.
- 加强监测和查策略是必要的,以应对国内和国际的C. auris威胁.
相关概念视频
Healthcare Associated Infections II: Preventive Measures
3.6K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
3.6K
Antimicrobial Effectiveness
889
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
889
Surface Membrane Barriers
2.6K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
2.6K
Defense Against Bacterial Pathogens
2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K
Transmission-based Precautions II: Airborne and Protective Environment
1.8K
Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
1.8K


