小脑tDCS和疼痛调节:一个关键的整合和系统的审查
Daniel Fernando Arias Betancur1,2, Maria da Graça Lopes Tarragó3, Maria Eduarda Louzada Oliveira2
1Graduate Program in Medical Sciences, School of Medicine, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Frontiers in neurology
|November 17, 2025
概括
脑小叶横直流刺激 (ctDCS) 通过调节疼痛通路,显示出疼痛管理的潜力. 需要进一步的研究来确认其临床有效性和优化方案.
科学领域:
- 神经科学是一个神经科学.
- 神经调节是一种神经调节.
- 疼痛研究 疼痛研究
背景情况:
- 脑小叶横直流刺激 (ctDCS) 是一种用于疼痛管理的非侵入性神经调节技术.
- 现有证据表明,在各种人群中,对疼痛感知有潜在的益处,但机制和疗效需要澄清.
研究的目的:
- 系统地审查小脑参与疼痛处理.
- 评估ctDCS在疼痛管理中的治疗潜力.
主要方法:
- 在PubMed,Embase和Cochrane图书馆进行系统的文献搜索,截至2024年12月11日.
- 包括随机对照试验 (RCT) 调查ctDCS对疼痛的影响,使用PRISMA指南和Cochrane风险偏差工具v2.2进行评估.
- 关键词包括"小脑"",疼痛"和"tDCS".
主要成果:
- 包含了五个RCT,并指出了方法上的局限性,包括报告不一致性和盲目的问题.
- 阳道ctDCS通常会增加疼痛值和内源性疼痛抑制.
- 阴极ctDCS倾向于降低疼痛值,受到EEG数据显示调制皮质活动的支持.
结论:
- 初步发现表明ctDCS可以调节 nociceptive 途径并增强疼痛抑制.
- 数量少的研究和异质性限制了概括性;高质量的RCT对于协议优化和确定临床益处是必要的.
- 小脑被确定为神经调节性疼痛干预的有希望的,但尚未探索的目标.
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