相关实验视频

Updated: Jan 11, 2026

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
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Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

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通过使用图形注意力神经网络,通过弹头参与药物目标相互作用的水平来预测PROTAC非目标效应

Yutong Hu1,2, Kieran Didi3, Adam P Cribbs4

  • 1Thrust of Bioscience and Biomedical Engineering, Hong Kong University of Science and Technology (Guangzhou), Guangzhou 511400, China.

Computational and structural biotechnology journal
|November 17, 2025
PubMed
概括

一个新的深度学习框架SENTINEL预测了针对蛋白质溶解向仿真体 (PROTACs) 的非目标蛋白质降解风险. 该工具有助于在药物开发的早期优先考虑更安全的PROTAC弹头.

关键词:
深度学习是一种深度学习.降解降解是一种降解.图表注意力网络的图表.非目标效应的影响这就是 PROTACs.

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