中性粒细胞-淋巴细胞比和亚临床动脉样硬化在基本高血压患者
Luigi Petramala1, Francesco Circosta2, Leonardo Cremonesi2
1Department of Translational and Precision Medicine, "Sapienza" University of Rome, Rome, Italy.
Frontiers in cardiovascular medicine
|November 17, 2025
概括
中性粒细胞-淋巴细胞比率 (NLR) 与高血压患者的高血压和更多的器官损伤有关. 这种可访问的生物标志物可能有助于识别那些患心血管问题的风险较高的人.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 高血压研究 高血压研究
背景情况:
- 动脉高血压是器官损伤和动脉样硬化的关键驱动因素.
- 中性粒细胞-淋巴细胞比率 (NLR) 是心血管疾病不良结果的经过验证的生物标志物.
- 基本高血压患者经常有未诊断的亚临床器官损伤.
研究的目的:
- 评估NLR作为亚临床动脉样硬化损伤在基本高血压中的生物标志物的临床实用性.
- 研究高血压个体中NLR和心血管并发症之间的相关性.
主要方法:
- 在2024年1月至11月期间,346名基本高血压患者被录取.
- 收集的数据包括病史,人体测量,生物化学分析和亚临床器官损伤标志物.
- 排除标准包括现有的心血管或脑血管疾病.
主要成果:
- 较高的NLR与高血压,多种药物,脂质不良和睡眠呼吸暂停相关.
- 升高的NLR与左心室质量增加,大脑动脉动脉样硬化和小albuminuria有关.
- NLR与心血管并发症和亚临床器官损伤有显著的相关性.
结论:
- 在基本高血压中,NLR是亚临床器官损伤的有价值的替代生物标志物.
- NLR可以帮助识别心血管风险增加的高血压患者.
- 进一步的研究可以探索NLR在指导高血压管理中的作用.
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