梅拉贝格伦在过度活跃膀和下尿道症状的男性中的有效性和安全性:来自综合数据库的分析
Farid Abdul Hadi1, Arianne Schild2, Merete Kock Hansen3
1International Markets and China Medical Affairs, Astellas Pharma Singapore Pte. Ltd., Singapore, Singapore.
European urology open science
|November 17, 2025
概括
米拉贝格伦有效治疗男性的过度活动膀 (OAB),包括那些良性前列腺扩大 (BPE) 和下泌尿道症状 (LUTS) 患者. 这种分析证实了Mirabegron的存在.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 过度活性膀 (OAB) 影响了许多成年男性.
- 良性前列腺扩大 (BPE) 是老年男性常见的并发症.
- 下尿路症状 (LUTS) 管理对于男性下尿路健康至关重要.
研究的目的:
- 评估Mirabegron在成年男性OAB患者中的疗效和安全性.
- 评估Mirabegron在有或没有BPE的男性中的有效性.
- 为了确定mirabegron在接受同时服用LUTS药物的患者中的效用.
主要方法:
- 对13项2期至4期研究进行了后期分析.
- 包括OAB男性的整体队列,与alpha阻断剂上的BPE,以及与其他LUTS药物上的BPE.
- 主要终点:每日排尿的变化和12周的失禁情节.
主要成果:
- 米拉贝格伦在初级和二级疗效终点上显著改善.
- 接受米拉贝格伦与α阻断剂治疗的患者每次分泌时空化体积增加.
- 安全性概况与已知的mirabegron数据一致;由于某些队列的样本规模较小,结果需要谨慎解释.
结论:
- 米拉贝格朗是男性OAB患者的安全有效的治疗选择.
- 无论 BPE 状态或同时服用 LUTS 药物,都证明了有效性.
- 支持mirabegron在管理复杂的男性下尿路疾病中的作用.
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