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Updated: Jan 11, 2026

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在MTAP缺乏癌症中通过谷氨酸代谢和CXCL10降低调节抑制免疫力

Wen-Hsin Chang1,2,3,4, Jun Zhang2,3, Qi-Sheng Hong1,2

  • 1Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of California, Davis, Davis, CA, United States.

Frontiers in immunology
|November 17, 2025
PubMed
概括

在MTAP缺乏癌症中准谷氨酸代谢可以克服对免疫检查点抑制剂 (ICI) 的耐药性. 这种方法不仅抑制了瘤的生长,还增强了免疫细胞的透,将"冷"的瘤转变为响应性瘤.

关键词:
在CXCL10中,CXCL10是CXCL10中的一个.在MTAP中存在缺陷.谷氨酸的代谢 谷氨酸代谢免疫抑制是一种免疫抑制.瘤微环境是一个微环境.

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