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准Pin1以克服MSS结直肠癌中的免疫抑制瘤微环境

Jian Wang1,2, Shuxin Tang3, Jinhua Fan4

  • 1Department of Oncology, Chongqing University Jiangjin Hospital, Chongqing, China.

Frontiers in immunology
|November 17, 2025
PubMed
概括

Pin1通过创建免疫抑制瘤微环境 (TME) 来促进微卫星稳定性 (MSS) 和结直肠癌 (CRC). 抑制Pin1可以通过向NF-κB-CCL3-CCR5通路来克服MSSCRC中的免疫疗法耐药性.

关键词:
在MSS的结直肠癌 (CRC).在NF-κB-CCL3-CCR5轴上一个Pin1一个Pin1免疫抑制性瘤微环境 (TME)免疫疗法耐药性 免疫疗法耐药性

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