与米达佐拉姆相比,雷米马佐拉姆作为直接的自由基清除剂的抗氧化活性与米达佐拉姆相比
Shigekiyo Matsumoto1, Yuta Ukon2, Shiena Endo2
1Anesthesiology, Oita University, Oita, JPN.
Cureus
|November 17, 2025
概括
雷米马佐拉姆是一种超短效麻醉剂,具有显著的直接自由基清除活性,特别是在基基上. 这种抗氧化特性可能会提供除了麻醉之外的额外好处.
科学领域:
- 药理学 药理学是指药理学的学科.
- 麻醉学 麻醉学
- 生物化学 生物化学
背景情况:
- 雷米马佐拉姆是一种新型的超短效二甲,用于全身麻醉.
- 它以血液动力学稳定性和快速恢复而闻名,特别是在心脏功能不佳的患者和老年人中.
- 以前的研究表明,雷米马拉姆可以抑制炎症和氧化应激,但其直接的自由基清除活性没有得到充分报告.
研究的目的:
- 评估雷米马佐拉姆的直接非酶性自由基清除活性.
- 为了比较其对多种自由基物种和单片氧的活性.
- 为了比较雷米马佐拉姆与米达佐拉姆和埃达拉的活性.
主要方法:
- 在一次性细胞中产生了自由基和单片氧.
- 雷米马索拉姆在各种度中添加,并使用电子自旋共振光谱法与自旋捕获方法测量了清理活性.
- 计算了反应速率常数以量化清除活性;还评估了米达佐拉姆的活性以进行比较.
主要成果:
- 雷米马拉姆清除了基激素,超氧化离子, Askorbyl 自由基和单片氧.
- 它对基的反应速率常数与埃达拉相当,并且明显高于米达佐拉姆.
- 雷米马佐拉姆并没有清除氧化,2,2-二-1-皮克里,或铁基.
结论:
- 雷米马佐拉姆表现出显著的直接自由基清除活性,超过了米达佐拉姆.
- 它强大的清除基基和超氧化离子表明在麻醉管理中具有潜在的抗氧化作用.
- 这些发现有助于了解雷米马佐拉姆除了麻醉特性之外的药理学特征.
更多相关视频
06:45Use of Electron Paramagnetic Resonance in Biological Samples at Ambient Temperature and 77 K
Published on: January 11, 2019
9.7K
13:21Detection of Nitric Oxide and Superoxide Radical Anion by Electron Paramagnetic Resonance Spectroscopy from Cells using Spin Traps
Published on: August 18, 2012
19.4K
相关概念视频
01:20Radical Autoxidation
3.0K
The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
3.0K
01:16Radical Reactivity: Nucleophilic Radicals
2.6K
Radicals adjacent to electron-donating groups are called nucleophilic radicals. These radicals readily react with electrophilic alkenes. The SOMO–LUMO interactions are the driving force for the reaction, where the high-energy SOMO of the electron-rich, nucleophilic radicals interacts with the low-energy LUMO of the electron-deficient, electrophilic alkenes. Such SOMO–LUMO interactions are the basis of reactive radical traps, affecting the selectivity in radical reactions. For...
2.6K
01:02Radical Reactivity: Electrophilic Radicals
2.4K
Radicals adjacent to electron‐withdrawing groups are called electrophilic radicals. These radicals readily react with nucleophilic alkenes. For example, the malonate radical, in which the radical center is flanked by two electron‐withdrawing groups, reacts readily with butyl vinyl ether, which consists of an electron‐donating oxygen substituent. The reaction between electrophilic malonate radical and nucleophilic vinyl ether is favored because the radical has a...
2.4K
01:17Oxidation of Phenols to Quinones
4.5K
In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
4.5K
01:10Radical Reactivity: Steric Effects
2.4K
The presence of electron-donating, electron-withdrawing, or conjugating groups adjacent to a radical center, imparts electronic stabilization to the radicals. Examples of such electronically-stabilized radicals are triphenylmethyl, tetramethylpiperidine‐N‐oxide, and 2,2‐diphenyl‐1‐picrylhydrazyl. These radicals are remarkably stable and are known as persistent radicals. Some of the persistent radicals can even be isolated and purified.
Along with electronic...
Along with electronic...
2.4K
01:11ortho–para-Directing Activators: –CH3, –OH, –NH2, –OCH3
7.3K
All ortho–para directors, excluding halogens, are activating groups. These groups donate electrons to the ring, making the ring carbons electron-rich. Consequently, the reactivity of the aromatic ring towards electrophilic substitution increases. For instance, the nitration of anisole is about 10,000 times faster than the nitration of benzene. The electron-donating effect of the methoxy group in anisole activates the ortho and para positions on the ring and stabilizes the corresponding...
7.3K