富含点氨酸,低雌性化度的主导性肠道补充剂协调了急性性结肠炎的改善
Huizi Tan1, Menglin Chen1, Hong Yao1
1State Key Laboratory of Food Science and Resources, China-Canada Joint Laboratory of Food Science and Technology (Nanchang), Nanchang University, Nanchang 330047, China.
低化pectin通过调节肠道细菌和宿主新陈代谢来保护大肠炎. 一个特定的细菌联盟显示了作为便微生物群移植 (FMT) 替代治疗炎症性肠病 (IBD) 的承诺.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 营养科学 营养科学
背景情况:
- 食纤维的健康益处越来越多地与肠道微生物群活动有关.
- 纤维结构显著影响其对健康的影响.
- 与高化素相比,低化素显示出对DSS诱导的大肠炎的更强的保护,但潜在的机制仍然不清楚.
研究的目的:
- 阐明依赖于微生物群的机制,通过这些机制,低化pectin对结肠炎产生保护作用.
- 调查特定的素诱导细菌在调解这些保护作用中的作用,单独和作为一个联盟.
- 探索一个富含点氨酸的细菌联盟的潜力,作为用于炎症性肠病 (IBD) 的便微生物群移植 (FMT) 的替代方案.
主要方法:
- 利用便微生物群移植 (FMT) 来研究微生物群依赖的途径.
- 评估了三种素诱导细菌的单独和综合作用: *Bifidobacterium longum* NSP002, *Bacteroides xylanisolvens* NSP003,和 *Enterococcus faecium* NSP004. 这三种细菌的单独和综合作用.
- 评估了肠道微生物组合,肠道平衡标志物和全身代谢概况.
主要成果:
- 这三种细菌的联盟比单个菌株提供了明显更好的抗结肠炎保护,这表明了协同作用.
- 低化pectin的保护作用与肠道微生物组重塑有关 (例如,减少了Akkermansia,增加了Bacteroides,增加了propionic acid).
- 肠道平衡被调节 (减少mme/calprotectin,激活PI3K/信号),并且发生了全身代谢重编程 (增加血清甲基胺,丰富氨代谢).
结论:
- 一个富含点氨酸的细菌联盟表现出显著的抗结肠病作用,表明其作为FMT替代品的潜力.
- 保护机制涉及整个肠道微生物群,肠道平衡和全身代谢的复杂相互作用.
- 这些发现支持点和向微生物联盟的临床应用,用于管理IBD和优化肠道营养.
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