奎尔素通过调节肠道微生物群和托代谢来缓解性结肠炎
Man Xiong1, Wenli Kuang2, Zhenyang Liu2
1Guangzhou University of Chinese Medicine, Guangzhou, PR China.
mSystems
|November 17, 2025
概括
奎尔素通过促进有益的肠道细菌和托代谢物来缓解小鼠的性结肠炎症状. 这激活了基碳化合物受体,恢复了肠道健康并减少了炎症.
科学领域:
- 自然产品化学 自然产品化学
- 胃肠病学 胃肠病学
- 微生物组研究的研究.
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性肠病,治疗选择有限.
- Quercetin 是一种来自传统中医药的黄类药物,显示了UC症状缓解的潜力.
- 奎尔丁在UC中的确切作用机制尚不清楚.
研究的目的:
- 为了研究氨酸如何影响三甲代谢和肠道细菌群体在化学诱导性结肠炎的小鼠模型.
- 阐明氏素在UC中发挥治疗作用的分子途径.
- 探索奎尔塞丁作为针对UC的微生物向治疗的潜力.
主要方法:
- 在小鼠中的化学诱导性结肠炎模型.
- 克韦尔丁的使用.
- 评估临床症状,体重,脏指数和结肠组织学.
- 先进的微生物组分析 (16S rRNA测序).
- 代谢分析以量化托代谢产物.
- 对基碳化合物受体 (AhR) 路径激活的分析.
主要成果:
- 奎尔丁治疗使体重正常化,减少了脏扩大,改善了临床结肠炎得分.
- 组织学分析显示,瑞丁治疗小鼠的结肠结构得到保存,组织损伤愈合.
- 微生物组分析显示,有益的肠道微生物种群增加.
- 代谢分析表明,托芬副产品的度更高,包括乳酸.
- 增加的乳酸激活了基碳化合物受体 (AhR) 途径.
- 激活AhR与恢复肠道内膜完整性和减少炎症有关.
结论:
- 在大肠炎的小鼠模型中,奎尔素有效地缓解症状并恢复结肠完整性.
- 奎尔赛丁重塑肠道微生物群的组成,增强托的代谢.
- 治疗效果是由增加的微生物产生的乳酸,激活AhR通路的介导.
- 这项研究揭示了一个关键的肠道微生物群衍生代谢物-宿主信号轴在奎尔塞丁的作用机制.
- 奎尔是UC的有希望的治疗剂,通过微生物群调节和代谢物驱动的信号传递起作用.
相关概念视频
Drugs for Treatment of Ulcerative Colitis in IBD
439
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
439
Inflammatory Bowel Disease IV: Pharmacological Management
459
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
459
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
622
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
622
Gene Regulation in Microbial Communities: Quorum Sensing
486
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
486
Inflammatory Bowel Disease I: Ulcerative Colitis
880
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
880
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
470
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
470


