生活方式,新陈代谢和糖尿病病:一个队列研究
Bowen Deng1, Yidan Zheng2, Zihao Zhou2
1Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
QJM : monthly journal of the Association of Physicians
|November 17, 2025
概括
生活方式行为通过代谢途径显著影响糖尿病病 (DKD). 通过代谢学来理解这些联系可以指导针对糖尿病患者脏健康的有针对性的干预措施.
科学领域:
- 代谢学和分子生物学
- 流行病学和公共卫生.
- 内分泌学和脏学.
背景情况:
- 糖尿病病 (DKD) 是衰竭的主要原因,与生活方式密切相关,但潜在的机制尚不清楚.
- 对于有效的预防和治疗策略来说,研究生活方式选择和DKD病变之间的复杂关系至关重要.
研究的目的:
- 综合评估生活方式行为对糖尿病病发病率和死亡率的长期代谢后果.
- 阐明代谢生物标志物在生活方式因素和DKD之间的关联中的调解作用.
主要方法:
- 分析了来自18287名糖尿病患者的数据,评估了5个生活方式因素和251个代谢生物标志物.
- 利用考克斯的比例危险模型,门德尔的随机化 (MR) 和调解分析来检查关联和因果关系.
- 采用全基因组协会研究 (GWAS) 和基因丰富分析来探索介导生物标志物的生物机制.
主要成果:
- 在平均14.6年的时间里,3247名参与者患上了DKD.
- 脂质和氨基酸被确定为关键的代谢媒介,将生活方式因素与DKD发病率和死亡率联系起来.
- 特定的生物标志物,包括高脂相关的脂质百分比和糖蛋白乙,显示出与DKD有显著的观察和因果关联,基于血糖控制产生不同的影响.
结论:
- 代谢学提供了对生活方式行为如何影响DKD机制的关键见解.
- 这些发现突出了基于代谢概况的有针对性的干预措施的潜力,以减轻糖尿病人群中DKD进展的可能性.
相关概念视频
Chronic Kidney Disease II: Clinical Manifestations
537
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
537
Chronic Kidney Disease I: Introduction
552
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
552
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
163
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
163
Diabetes Mellitus: Type 2 and Gestational
4.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.3K
Chronic Kidney Disease III: Interprofessional Care
331
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
331
Pathophysiology of Diabetes
3.1K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.1K


