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优化神经肌肉连接的形成,以增强信号传导在再生的外周神经接口

Ken Kuan-Wei Chen¹, Paul S Cederna², Yu-Han Huang¹

¹Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan, and Chang Gung University, Taoyuan, Taiwan.

Plastic and reconstructive surgery

|November 17, 2025

概括

再生性外周神经接口 (RPNI) 手术通过放大神经信号来改善假肢控制. 在RPNI手术中分裂神经源可增强神经肌肉结节的再内内和信号放大.

科学领域:

生物医学工程生物医学工程
神经科学是一个神经科学.
再生医学是一种再生医学.

背景情况:

再生外围神经接口 (RPNI) 手术增强了来自外围神经的运动信号放大,以改善肌电假肢控制.
通过神经肌肉结 (NMJ) 评估了解RPNI机制对于优化假肢功能至关重要.

研究的目的:

通过详细的神经肌肉结 (NMJ) 分析,阐明RPNI运动功能的机制.
引入和评估一种新的方法来增强RPNI中的再内内和信号放大.

主要方法:

成人C57BL/6J小鼠接受了RPNI手术,其中使用了免费的延伸长肌 (EDL) 肌肉移植,通过常见腹神经 (CPN) 进行神经化,三种配置:标准RPNI,双状RPNI和无神经化的RPNI.
对照组包括完整的EDL肌肉和切割和修复的 (C&R) CPN.
在8周和12周的评估包括电诊断测试,肌肉重量,免疫光染色和西部斑点分析.

主要成果:

RPNI手术证实了为有效的神经信号放大而足够的NMJ内化.
与标准RPNI相比,双状RPNI表现出优异的结果,包括更高的复合肌动力潜力 (CMAP),增加目标肌肉重量和改善的NMJ再内尔化.
在双囊RPNI组中观察到减少了运动端板碎片化.

结论:

在RPNI中,神经肌肉结节的再内化和运动末端板形态学为神经信号传输提供了洞察力.
分解神经源显著增强RPNI内的NMJ再内核,为假肢应用改善信号放大提供了一个有前途的策略.

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