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Updated: Jan 11, 2026

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酸果酶-1组件的多尺度模拟:捕捉特定和短暂相互作用之间的相互作用.

Mehrnoosh Khodam Hazrati1, Tom Miclot1, Stepan Timr1

  • 1J. Heyrovsky Institute of Physical Chemistry, Czech Academy of Sciences, Dolejskova 2155/3, Prague 182 00, Czech Republic.

The journal of physical chemistry. B
|November 17, 2025
PubMed
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人类果酸酶-1 (PFK1) 形成了对糖解组织至关重要的纤维. 模拟揭示了当前模型的局限性,提出了改进的粗粒度方法,以提高蛋白质组装研究的准确性.

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Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
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