怀孕期间接触电子烟会损害子宫动脉的血液流动和胎盘功能
Zianne A Olverson1, Sierra J Saldaña1, Roy A Miller1
1Division of Cardiac Surgery, Department of Surgery, College of Medicine and The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
怀孕期间使用电子烟 (e-cig) 会损害母亲的心血管功能,减少子宫血流,并损害胎儿的发育. 即使没有尼古丁,暴露在电子烟气溶中也会对怀孕结果产生负面影响.
科学领域:
- 生殖科学 生殖科学
- 心血管生理学心血管生理学
- 毒理学 毒理学 毒理学
背景情况:
- 电子烟 (e-cig) 的受欢迎程度正在上升,在生殖年龄的个人中使用越来越多.
- 怀孕期间电子烟的安全性尚不清楚,尽管有独特的气溶成分的潜在风险.
- 胎盘发育和血管功能对于健康的妊娠结果至关重要.
研究的目的:
- 研究子宫内暴露于亚欧姆电子烟气溶 (含尼古丁或不含尼古丁) 对母亲和胎儿心血管功能,子宫血管功能和胎盘形态的影响.
- 为了确定电子烟车辆的组件是否单独导致不良孕期影响.
主要方法:
- 怀孕的FVB/J小鼠从胚胎0.5日到E17.5.5日暴露在过空气,电子烟车辆 (乙醇/植物甘油) 或含尼古丁的车辆中.
- 使用心声学和超声波评估了母亲和胎儿的心血管参数.
- 胎盘和组织分析包括组织学和分子评估.
主要成果:
- 接触电子烟导致母亲的透气功能障碍和子宫动脉血流减少.
- 观察到胎儿心,胎盘结构变化和胎盘足够性降低.
- 在尼古丁和非尼古丁电子烟气溶暴露组中都出现了不良反应.
结论:
- 在子宫内接触电子烟会破坏母亲的心血管适应和胎儿发育.
- 电子烟气溶车辆组件,独立于尼古丁,可以损害妊娠健康.
- 怀孕期间使用电子烟的安全性需要重新评估,需要进一步的机制研究.
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