成年囊性纤维化患者的嗅觉功能障碍
A Minzoni1, P Orlando1, L Mazzetti1
1Department of Otorhinolaryngology, Careggi University Hospital, Florence, Italy.
Rhinology
|November 17, 2025
概括
患有慢性鼻炎的囊性纤维化患者经过12个月的elexacaftor/tezacaftor/ivacaftor (ETI) 治疗后,嗅觉功能得到改善,这表明CF相关的嗅觉功能障碍对嗅觉有积极影响.
科学领域:
- 肺部病理学 肺部病理学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 医学遗传学 医学遗传学
背景情况:
- 嗅觉功能障碍 (OD) 在患有慢性鼻炎 (CRS) 的囊性纤维化 (CF) 患者中很常见.
- CFTR调节器治疗对CF相关的CRS中嗅觉结果的影响尚不清楚.
- 慢性鼻炎是囊性纤维化患者经常出现的并发症.
研究的目的:
- 在12个月的elexacaftor/tezacaftor/ivacaftor (ETI) 治疗后,评估CF患者的嗅觉功能的变化.
- 探索与嗅觉功能变化相关的临床和生物因素.
- 评估ETI治疗对CF相关CRS的气味的影响.
主要方法:
- 这是一项前性研究,涉及45名被诊断患有CRS的成年CF患者.
- 嗅觉功能使用16项嗅探棒识别测试 (SSIT) 进行治疗前和后的评估.
- 患者接受了12个月的elexacaftor/tezacaftor/ivacaftor (ETI) 治疗.
主要成果:
- 经过12个月的ETI治疗后,嗅觉功能显著改善.
- 这项研究探讨了气味改善与临床/生物因素之间的相关性 (细节待详细阐述).
- 在评估嗅觉变化方面,ETI治疗证明了可行性和纵向适用性.
结论:
- 治疗elexacaftor/tezacaftor/ivacaftor (ETI) 对CF患者具有CRS的嗅觉功能产生了积极的影响.
- CFTR调制剂疗法为改善CF相关的嗅觉功能障碍的气味提供了潜在的途径.
- 需要进一步的研究来阐明嗅觉改善的机制和临床相关性.
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