晚年自闭症诊断在患有多种同时发生的精神疾病的儿童中
Brian C Kavanaugh1,2,3, Danielle G St Pierre1,2,3, Christine Schremp1,2
1Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, USA.
Journal of autism and developmental disorders
|November 17, 2025
概括
患有更多同时出现的精神疾病的儿童后来被诊断为自闭症谱系障碍 (ASD). 这突出了多种并发症儿童中自闭症潜在的独特亚型.
科学领域:
- 神经发育障碍 神经发育障碍
- 儿童精神病学 儿童精神病学
- 遗传学和基因组学 遗传学和基因组学
背景情况:
- 早期诊断自闭症谱系障碍 (ASD) 对于及时的治疗干预和改善结果至关重要.
- 影响自闭症诊断年龄的因素仍然不完全理解,需要进一步调查.
研究的目的:
- 调查同时出现的精神疾病和ASD诊断年龄之间的关系.
- 分析与ASD儿童诊断延迟相关的临床特征.
主要方法:
- 分析了两个大型的独立数据集:罗德岛自闭症研究和治疗联盟 (RI-CART) 和西蒙斯基金会推动自闭症知识研究 (SPARK).
- 在5万多名患有自闭症的参与者中,检查了人口统计,口语状态,智力障碍,行为特征和精神病药物使用情况.
- 研究的同时发生的疾病包括双相情绪障碍,抑郁症,焦虑症,强迫症,多动症,多动症和行为障碍.
主要成果:
- 在这两组数据中,同时出现的精神病的数量和以后的ASD诊断之间发现了显著的关联.
- 与没有三个或更多同时出现的疾病的儿童相比,患有三个或更多同时出现的疾病的儿童的诊断时间明显晚 (例如,RI-CART的8.5年,SPARK的10年) 与没有任何疾病的儿童相比 (RI-CART的4.3年,SPARK的4年).
- 抑郁症和ADHD与后来的ASD诊断有关,而强迫症 (OCD) 和智力障碍 (ID) 与早期诊断有关,在控制共变量后.
结论:
- 患有并发精神疾病负担较高的儿童在ASD诊断中经历了延迟.
- 这一子组患有多种并发症的儿童可能代表自闭症谱系障碍的独特临床亚型.
- 这些发现强调了全面精神病学评估在ASD诊断过程中的重要性.
更多相关视频
05:32Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos
Published on: December 7, 2018
9.5K
06:15Using the Visual World Paradigm to Study Sentence Comprehension in Mandarin-Speaking Children with Autism
Published on: October 3, 2018
8.1K
相关概念视频
Autism Spectrum Disorder
931
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
931
Attention-Deficit/Hyperactivity Disorder
725
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
725
Oppositional Defiant Disorder
596
A persistent pattern of angry or irritable mood, defiant behavior, or vindictiveness characterizes Oppositional Defiant Disorder (ODD). Symptoms must occur over at least six months, involve interactions with individuals beyond siblings, and meet specific diagnostic criteria to be clinically significant. The disorder affects emotional regulation, social interactions, and behavior, often manifesting early in life and influencing long-term development and functioning.
Diagnostic Criteria and...
Diagnostic Criteria and...
596
Diagnostic and Statistical Manual of Mental Disorders (DSM)
995
The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
995
Conduct Disorder
465
Conduct disorder is a complex mental health diagnosis characterized by a repetitive and persistent pattern of behavior that violates societal norms, the rights of others, or age-appropriate rules. The diagnostic criteria for conduct disorder require the presence of at least three problematic behaviors within the past 12 months, with at least one occurring in the past six months. These behaviors are grouped into four categories: aggression toward people and animals; destruction of property;...
465
Modeling in Therapy
368
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
368
