儿科HFMD病例中肠道病毒的初步遗传特征:来自沙特阿拉伯吉达的第一个数据
Abdulsalam O Alsulami1,2, Hessa Awad Al-Sharif1,3, Saddiq Habiballah2,4
1Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
Journal of epidemiology and global health
|November 17, 2025
概括
沙特阿拉伯的手足口病 (HFMD) 主要是由肠道病毒 (EV) 引起的,其中Coxsackievirus A6 (CV-A6) 是最常见的血清型. 这项研究强调了EV的遗传多样性以及需要加强监测和疫苗战略.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 手足口病 (HFMD) 是全球常见的儿科病毒性疾病,通常是由肠道病毒 (EV) 引起的.
- 关于沙特阿拉伯的HFMD流行病学和病毒多样性的数据有限.
- 这项研究提供了沙特阿拉伯HFMD的第一个分子流行数据.
研究的目的:
- 在沙特阿拉伯吉达的儿科HFMD病例中确定肠道病毒 (EV) 感染的基因组血清型.
- 调查EV血型与儿童疾病结局之间的关联.
- 为该地区未来的HFMD监测建立基线分子数据.
主要方法:
- 从34名儿科HFMD患者使用实时RT-PCR和常规RT-PCR的口腔和喉拭片的分析.
- 检测到的肠道病毒的5'-非编码区域 (5'-NCR) 的测序.
- 植物遗传学分析用于全面的血清型识别和菌株比较.
主要成果:
- 在82.35% (28/34) 的儿科HFMD病例中检测到肠道病毒.
- 鉴定了五种EV血清型:CV-A6 (50%),CV-A16 (35.7%),CV-A10 (7.1%),EV-A71 (3.6%) 和CV-A5 (3.6%).这些血清类型包括:
- 考克萨基病毒A6 (CV-A6) 是主要的血清型,特别是在3岁以下的儿童中. 沙特菌株与全球隔离品有着密切的遗传关系.
结论:
- 吉达呈现出显著的遗传多样性和多个EV血清型的共同循环,导致HFMD.
- 在这个群体中,CV-A6的占主导地位与全球趋势一致.
- 需要持续的分子监测和制定公共卫生准备战略,包括针对流行和新出现的血清型的疫苗.
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