升高的中性粒细胞外细胞陷预测死亡率和重病AKI患者的CKD进展:一项前性观察性研究
Hesham Kamal Habeeb Keryakos1, Neama Ahmed AbdEl-Aziz2, Amel Mahmoud Kamal El-Din3
1Department of Internal Medicine, Faculty of Medicine, Minia University, Minya, Egypt. hesham.keryakos@mu.edu.eg.
International urology and nephrology
|November 17, 2025
概括
中性细胞细胞外陷 (NETs) 在急性损伤 (AKI) 患者中升高,并预测慢性病 (CKD) 的进展和死亡率. 较高的NET水平表明危急病患者的疾病严重程度和风险增加.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
- 关键护理医学 关键护理医学
背景情况:
- 炎症是急性损伤 (AKI) 病理生理学的核心.
- 中性粒细胞外细胞陷 (NETs) 与炎症和组织损伤有关.
- 在AKI中NETs的确切作用需要进一步阐明.
研究的目的:
- 为了评估重症AKI患者的NET水平.
- 为了将NET水平与AKI严重程度和临床结果相关联.
- 调查NET与慢性病 (CKD) 的进展之间的关联.
主要方法:
- 对73名AKI患者和33名对照进行前性观察性研究.
- 在入院和康复后由ELISA测量的NET水平.
- 分析与AKI严重程度 (KDIGO),炎症标志物和结果 (死亡率,ICU停留,CKD) 的相关性.
主要成果:
- AKI患者的NET水平明显高于对照组 (p < 0.001).
- 升高的NET与AKI严重程度,APACHE II分数和死亡率相关.
- NET预测了CKD进展 (AUC=0.919) 和死亡率 (AUC=0.855);非幸存者的中位数NET高出82%.
结论:
- 在AKI中,NET升高,并作为CKD进展,感染风险和死亡率的独立预测指标.
- 在AKI中,NET显示出作为动态预后生物标志物的潜力.
- 网络代表了AKI管理的潜在治疗目标.
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