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Updated: Jan 11, 2026

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
用烯增强的新体载体用于跨 tympanic 药物输送:全面的优化和体内评估
Sadek Ahmed1, Ali Fayez2, Heba Attia3
1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr El-Aini, Cairo, Egypt, P.O. Box 11562. sadek.sadek@pharma.cu.edu.eg.
芬增强的新索姆改善了用于中耳炎治疗的勒沃素输送. 这种非侵入性方法显示了增强的抗菌疗效和生物膜抑制,为中耳感染提供了有希望的解决方案.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 纳米技术 纳米技术
背景情况:
- 中耳炎 (OM) 是一种常见的中耳感染,特别是在儿童中.
- 目前的治疗方法在有效地将抗生素通过耳膜传递方面面临着挑战.
- 开发新的药物输送系统对于改善治疗结果至关重要.
研究的目的:
- 为了配制封装勒沃素 (LFX) 的芬增强新体.
- 为了增强LFX在中耳炎治疗中的跨 tympanic 透和抗菌疗效.
- 优化新体配方,以改善药物输送特性.
主要方法:
- 使用乙醇注射技术制备了新生体.
- 为了优化配方参数 (胆固醇酸:药物比率,胆固醇:芬比率,表面活性剂度),采用了2 ^ 3的因数设计.
- 粒子大小 (PS),多分散度指数 (PDI),捕获效率 (EE%) 和泽塔潜力 (ZP) 是关键的优化指标.
主要成果:
- 优化的配方表现出高可取性 (0.964),以73.39%的EE%,179.25 nm PS和-31.95 mV ZP.
- 试验室研究显示了双相释放,良好的稳定性和球形形态.
- 与LFX溶液相比,ex vivo研究表明透和流量增强.
- 在体外抗菌试验显示,针对S. aureus和P. aeruginosa的MIC和MBC值显著较低,具有优越的生物膜抑制.
结论:
- 芬增强的新细胞体有效地封装了levofloxacin.
- 优化的配方增强了药物透率和抗菌活性,对抗常见的中耳炎病原体.
- 这种新型纳米载体系统为管理中耳感染提供了一个有希望的非侵入性策略.
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