在患有晚期心力衰竭的患者中比较铁缺乏标志物
Maria Bakosova1,2, Jan Krejci3,4, Julius Godava1
1First Department of Internal Medicine-Cardioangiology, St. Anne's University Hospital, Brno, Czech Republic.
概括
铁缺乏症 (ID) 在晚期心力衰竭 (HF) 中很普遍,影响表现. 血清铁和转激素和度 (TSAT) 是可靠的标志物,用于ID在HF患者,不像ferritin.
科学领域:
- 心脏病学 心脏病学
- 血液学 血液学 血液学
- 内部医学 内部医学
背景情况:
- 缺铁 (ID) 是心力衰竭 (HF) 患者经常出现的并发症.
- 在HF中,ID与体力表现下降,住院病例增加和生活质量下降有关.
- 在HF中ID的精确定义仍然是正在进行的临床讨论的主题.
研究的目的:
- 改进在被诊断为晚期心力衰竭的患者中确定缺铁的方法.
- 评估铁代谢参数和其他临床特征之间的关系在先进的HF.
主要方法:
- 该研究包括102名晚期HF患者 (48名住院患者,29名没有LVAD的门诊患者,25名LVAD患者).
- 与传统测试一起监测铁代谢参数.
- 使用原始和更新的定义比较ID患病率;与功能能力相关的铁标记.
主要成果:
- 在晚期HF患者中,ID的患病率为65%.
- 血清铁和转激素和度 (TSAT) 显示出与功能状态的最强相关性.
- 与其他铁标记物相比,费里丁与功能状态和血液动力学相关性最弱.
结论:
- 晚期患有严重功能限制的HF患者表现出较差的铁参数.
- 血清铁和TSAT似乎是可靠的指标,用于检测ID在先进的HF.
- 在这个人群中,费里丁对ID的特异性较小,与功能能力和血液动力学相关性较弱.
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