与癌症相关的呼吸障碍的心身干预:随机对照试验的系统审查和元分析
Asli Papurcu1, Clarice Tang2,3,4, Birinder S Cheema5,6,7
1School of Health Sciences, Western Sydney University, Campbelltown, NSW, 2560, Australia. 20004255@student.westernsydney.edu.au.
概括
心身干预 (MBI) 没有显著改善癌症患者的呼吸障碍或生活质量. 研究中的方法限制表明,需要进一步的研究来确认MBI.
科学领域:
- 综合性瘤学和息护理研究.
- 探索用于癌症患者症状管理的补充疗法.
背景情况:
- 呼吸不良是癌症患者普遍和令人痛苦的症状,对身体功能,心理健康和生活质量 (QoL) 产生负面影响.
- 建议通过整合身体和精神实践的心身干预 (MBI),通过心身连接来影响福祉.
研究的目的:
- 系统地审查和元分析心身干预 (MBI) 对癌症患者呼吸障碍和相关结果的影响.
- 评估MBI对生活质量,运动能力和与呼吸障碍相关的焦虑水平的影响.
主要方法:
- 在2013年1月1日之后发表的随机对照试验 (RCT) 的七个电子数据库中进行了系统的文献搜索,结合了癌症,呼吸障碍和MBI的关键词.
- 使用偏差风险2 (RoB-2) 工具评估偏差风险,并使用审查经理5.4分析数据.
- 六个RCT符合纳入标准,调查了功,或联合呼吸和放松技巧.
主要成果:
- 分析表明,使用MBI没有显著改善呼吸障碍 (SMD = -0.48,p = 0.28),生活质量 (SMD = -1.04,p = 0.36),运动能力 (SMD = -0.02,p = 0.87),或焦虑 (SMD = -0.68,p = 0.12).
- 在包括的研究中观察到相当大的异质性.
- 一项研究被归类为具有高偏差风险的研究,并且在包括的RCT中注意到了方法上的限制.
结论:
- 目前的证据表明,MBI并不能显著减少癌症患者的呼吸障碍或焦虑.
- 现有RCT的方法缺陷可能影响了观察到的结果.
- 需要进一步的高质量,严格的研究来最终评估MBIs在癌症群体中控制呼吸障碍和相关症状的疗效.
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