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热适应改变了运动期间高温和功能生物标志物之间的关系热应激
K Riley Connor1,2, Shaun C Brazelton1,2, Andrew M Greenfield1
1Thermal and Mountain Medicine Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States.
概括
在运动热应激期间,热适应并没有改变功能标志物,如血清肌素. 然而,经过适应之后,脏可能会对热量变得更敏感,正如核心温度和肌素增加之间的相关性所示.
科学领域:
- 环境生理学环境生理学
- 脏生理学 脏生理学
- 运动生理学 运动生理学
背景情况:
- 在炎热的环境中进行艰苦的体力活动对功能构成风险,可能导致急性损伤 (AKI).
- 热适应是一种在暴露于热量的过程中减少生理应变的策略,但其对功能的影响尚未完全理解.
- 了解热度适应如何影响脏生物标志物对于保护在苛刻的热条件下工作的人来说至关重要.
研究的目的:
- 调查10天的热度适应是否会减轻运动热应激期间血清肌素 (ΔCr) 的增加.
- 评估热度适应对中性粒细胞凝酶相关性脂卡林 (ΔNGAL) 作为缺血的标志物的影响.
- 探索核心体温变化与热适应前后的功能生物标志物之间的关系.
主要方法:
- 20名健康的成年人 (14名女性) 在40°C的气候室中进行了10天的跑步机行走,以达到热度适应.
- 功能通过测量血清肌素 (ΔCr) 和血中性粒细胞凝酶相关性脂卡林 (ΔNGAL) 在1日和10日运动前后进行评估.
- 监测核心体温 (Tc),以评估热适应在减少热应变方面的有效性.
主要成果:
- 与第一天相比,10日的运动热应激期间,热适应减轻了核心体温的升高.
- 在第1天和第10天之间,在运动热应激后,血清肌素 (ΔCr) 或与中性粒细胞凝酶相关的血脂素 (ΔNGAL) 的增加没有显著差异.
- 在第10天的核心温度增加和ΔCr之间发现了显著的相关性,但不是在第1天,这表明脏对热量敏感性可能增加.
结论:
- 热适应似乎不会改变运动热应激后循环功能生物标志物的大小.
- 尽管 ΔCr 或 ΔNGAL 没有变化,但核心温度和 ΔCr 在第十天之间的相关性表明,热度适应的个体的脏可能对高温症更敏感.
- 需要进一步的研究,以充分阐明热度适应对脏对在炎热环境中炼的反应的细微影响.
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