作为潜在的调解者,ANPEP将阿斯巴甜暴露与MAFLD联系起来:来自网络毒理学和多omics分析的见解
Long Xu1, Chi Zhang1, Shengliang Xin1
1Department of Infectious Disease, Center for Liver Disease, Peking University First Hospital, Beijing, China.
International journal of surgery (London, England)
|November 17, 2025
概括
阿斯巴甜 (APM) 暴露可能会通过上调ANPEP,一种与肝炎和纤维化有关的蛋白质,增加代谢相关脂肪肝疾病 (MAFLD) 的风险. 这表明APM不是一种安全的体重管理策略.
科学领域:
- 生物化学 生物化学
- 毒理学 毒理学 毒理学
- 基因组学就是基因组学.
背景情况:
- 阿斯巴甜 (APM) 是一种常见的人造甜味剂,与代谢障碍有关.
- 连接APM与代谢相关脂肪肝疾病 (MAFLD) 的分子机制尚不清楚.
研究的目的:
- 调查将阿斯巴甜暴露与MAFLD联系在一起的分子标.
- 阐明这些点在MAFLD病变发生过程中的作用.
主要方法:
- 综合网络毒理学,分子对接,分子动力学,机器学习和转录学.
- 使用门德尔的随机化和组织学验证.
- 大量和单细胞RNA测序被用来分析基因表达.
主要成果:
- 阿斯巴甜 (APM) 显示出显著的肝毒性潜力.
- ANPEP被确定为一个关键的分子标,在MAFLD肝脏组织和小鼠模型中显示强烈的与APM结合和上调.
- 升高的ANPEP水平与MAFLD风险的增加显著相关,并且在早期纤维化阶段在髓状细胞中局部化.
结论:
- ANPEP 是一个潜在的调解者,将阿斯巴甜暴露与MAFLD,炎症,脂质失调和纤维化联系起来.
- 阿斯巴甜可能会造成肝损伤和MAFLD进展的风险,质疑其对体重管理的安全性.
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