Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Graph Neural Network-Assisted Machine Learning for High-Throughput Buried Interfacial Materials Screening in Antisolvent-Free Perovskite Solar Cells.

ACS applied materials & interfaces·2026
Same author

Large-Scale Proteomics Uncovers Pre-Disease Inflammation-Lipid Subtypes to Refine Risk Stratification and Prediction of Type 2 Diabetes.

Diabetes, obesity & metabolism·2026
Same author

Reducing P-O bond covalency in polyanionic groups to increase the intrinsic electronic conductivity in sodium positive electrodes.

Nature communications·2026
Same author

High-Performance Flexible Electromagnetic Wave Absorber through Synergistic Regulation of Matching and Reflective Layers.

ACS applied materials & interfaces·2026
Same author

Analysis of the effect of variable frequency fan on tobacco metabolites during curing via untargeted metabolomics.

BMC plant biology·2026
Same author

A prediction nomogram for faltering catch-up growth in full-term small-for-gestational-age infants: a retrospective cohort study.

Frontiers in pediatrics·2026
Same journal

AdaWGAN: Data Augmentation for Few-Shot HD-sEMG Gesture Recognition Using Single-Trial Data.

IEEE journal of biomedical and health informatics·2026
Same journal

NeuroBooster: a domain-informed self-supervised learning paradigm tailored for brain MRI analysis.

IEEE journal of biomedical and health informatics·2026
Same journal

Graph Convolutional Neural Network based Depression Detection using Brain Functional Connectivity Measures.

IEEE journal of biomedical and health informatics·2026
Same journal

Improving Multi-Sensor Non-Invasive Glucose Detection through AI: A Domain Generalization Approach.

IEEE journal of biomedical and health informatics·2026
Same journal

Unmixing the Neck: Accurate Jugular Venous Pulse Detection From Wearable PPG.

IEEE journal of biomedical and health informatics·2026
Same journal

AD-DAE: Alzheimer's Disease Progression Modeling with Unpaired Longitudinal MRI using Diffusion Auto-Encoders.

IEEE journal of biomedical and health informatics·2026
查看所有相关文章

相关实验视频

Updated: Jun 25, 2026

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

5.3K

图像增强的多模态对比变压器用于亚细胞空间转录组学.

Wanwan Shi, Ying Liu, Qiu Xiao

    IEEE journal of biomedical and health informatics
    |November 17, 2025
    PubMed
    概括
    此摘要是机器生成的。

    这项研究介绍了SIMMT,这是一个新的计算框架,集成了空间成像和基因表达数据. 通过改善空间聚类和识别瘤异质性的基因生物标志物,SIMMT增强了亚细胞数据分析.

    更多相关视频

    Dual-modality Molecular Cartography: Integrating Multiplex mRNA Detection with Protein Imaging Mass Cytometry
    06:51

    Dual-modality Molecular Cartography: Integrating Multiplex mRNA Detection with Protein Imaging Mass Cytometry

    Published on: November 14, 2025

    261
    Mining Spatial Transcriptomics Datasets using DeepSpaceDB
    10:16

    Mining Spatial Transcriptomics Datasets using DeepSpaceDB

    Published on: September 5, 2025

    626

    相关实验视频

    Last Updated: Jun 25, 2026

    Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
    09:19

    Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

    Published on: July 6, 2022

    5.3K
    Dual-modality Molecular Cartography: Integrating Multiplex mRNA Detection with Protein Imaging Mass Cytometry
    06:51

    Dual-modality Molecular Cartography: Integrating Multiplex mRNA Detection with Protein Imaging Mass Cytometry

    Published on: November 14, 2025

    261
    Mining Spatial Transcriptomics Datasets using DeepSpaceDB
    10:16

    Mining Spatial Transcriptomics Datasets using DeepSpaceDB

    Published on: September 5, 2025

    626

    科学领域:

    • 计算生物学是一种计算生物学.
    • 分子成像学分子成像学
    • 基因组学就是基因组学.

    背景情况:

    • 空间分子成像提供高分辨率的基因表达概况,但其基因检测有限.
    • 整合高分辨率成像功能与转录基因资料对于全面的亚细胞分析至关重要.

    研究的目的:

    • 开发SIMMT,一个图像增强的多模式对比变压器框架.
    • 通过整合形态学和转录学来识别空间领域并增强亚细胞数据.

    主要方法:

    • 设计了一种双变压器架构,以从转录学和形态学中学习多模式细胞表示.
    • 引入了对比性学习模块,以在细胞水平上调整组织形态和基因表达.

    主要成果:

    • 在多个数据集中,SIMMT在空间聚类和基因表达模式分析方面始终超越了最先进的方法.
    • 该框架有效地确定了人体肺癌和结直肠癌组织中的瘤空间异质性和潜在的基因生物标志物.

    结论:

    • SIMMT提供了一个强大的框架,用于集成空间成像和转录组数据,用于高级亚细胞分析.
    • 这种方法增强了对复杂生物组织中细胞异质性和生物标志物发现的理解.