Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Combinatorial Gene Control02:33

Combinatorial Gene Control

9.5K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
9.5K
Gene Therapy00:59

Gene Therapy

27.3K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.3K
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

978
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
978
Operant Conditioning Intervention01:24

Operant Conditioning Intervention

439
Operant conditioning serves as a foundational principle in therapeutic interventions aimed at modifying maladaptive behaviors. Central to this approach is the notion that behaviors, both adaptive and maladaptive, are learned through reinforcement. By analyzing the environmental factors that reinforce problematic behaviors, clinicians can design interventions to weaken these reinforcements and replace maladaptive behaviors with healthier alternatives.
In operant conditioning, behaviors that are...
439
Randomized Experiments01:13

Randomized Experiments

8.8K
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
8.8K
Neural Regulation01:37

Neural Regulation

43.0K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Prediction of Trends and Bioclimatic Factors Influencing the Monthly Incidence of Zoonotic Cutaneous Leishmaniasis Using Arima and Sarima Time Series Models in Maraveh Tappeh County, Golestan Province, Iran.

Journal of arthropod-borne diseases·2026
Same author

Recovering Reward Functions From Distributed Expert Demonstrations via Bi-Level Maximum-Likelihood Optimization.

IEEE transactions on neural networks and learning systems·2026
Same author

The crossroads between osteosarcopenia and intrinsic capacity-a narrative review.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026
Same author

The interplay between osteosarcopenia and intrinsic capacity: insights and associations with all-cause mortality in the Toledo Study for Healthy Aging.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026
Same author

Bayesian Topology Inference of Regulatory Networks under Partial Observability.

Results in control and optimization·2026
Same author

Pareto-Optimal Interventions in Gene Regulatory Networks using Signal Temporal Logic.

Proceedings of the ... American Control Conference. American Control Conference·2026

相关实验视频

Updated: Jan 11, 2026

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

2.6K

针对不对称基因网络干预的分散增强学习

Seyed Hamid Hosseini, Mahdi Imani

    IEEE transactions on computational biology and bioinformatics
    |November 17, 2025
    PubMed
    概括

    这项研究引入了一种新的深度强化学习框架,用于干预基因调节网络 (GRNs). 该方法通过适应细胞抵抗和不确定性来增强治疗策略,改善疾病治疗结果.

    科学领域:

    • 计算生物学 计算生物学
    • 系统生物学 系统生物学
    • 基因组学就是基因组学.

    背景情况:

    • 基因调节网络 (GRNs) 对细胞功能至关重要,但它们的失调与癌症等疾病有关.
    • 对GRNs的干预因细胞适应性抵抗和不完整的基因表达数据而复杂化.

    研究的目的:

    • 开发一个分散的深度强化学习框架,以有效地干预基因调节网络.
    • 为了应对干预期间细胞适应性抵抗和有限的状态信息所带来的挑战.

    主要方法:

    • 制定GRN干预作为一个不对称的两人零和游戏.
    • 推导出对具有完整基因状态知识的细胞的历史依赖性干预政策.
    • 使用深度政策梯度方法来接近纳什平衡政策.

    主要成果:

    • 建议的干预政策显示出强大的表现和高于预期的收益,即使对复杂的细胞适应反应.
    • 当系统状态信息完整时,该方法将汇聚到全态纳什平衡.
    • 对p53-MDM2和黑色素瘤GRN模型的验证表明在不确定性下具有优越的适应性.

    结论:

    • 开发的框架为设计基因调节网络的强大干预提供了一个强大的方法.

    更多相关视频

    A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning
    09:22

    A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning

    Published on: June 22, 2015

    15.0K
    Stereotaxic Injection of a Viral Vector for Conditional Gene Manipulation in the Mouse Spinal Cord
    08:39

    Stereotaxic Injection of a Viral Vector for Conditional Gene Manipulation in the Mouse Spinal Cord

    Published on: March 18, 2013

    31.7K

    相关实验视频

    Last Updated: Jan 11, 2026

    Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
    10:44

    Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

    Published on: December 7, 2021

    2.6K
    A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning
    09:22

    A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning

    Published on: June 22, 2015

    15.0K
    Stereotaxic Injection of a Viral Vector for Conditional Gene Manipulation in the Mouse Spinal Cord
    08:39

    Stereotaxic Injection of a Viral Vector for Conditional Gene Manipulation in the Mouse Spinal Cord

    Published on: March 18, 2013

    31.7K
  • 这种方法对改善GRN失调的复杂疾病的治疗策略有显著的前景.