静脉输注利多卡因在经历腰部手术的患者中加速术后肠功能恢复:多中心随机对照试验
Fei Huo1, Ran Zhang1, Yaqing Wu1
1Department of Anesthesiology, Peking University People's Hospital, Beijing, Beijing, China.
静脉输注利多卡因可显著加快腰部手术后肠道功能的恢复. 这种方法还减少了对手术内阿片类药物的需求,改善了患者的治疗结果.
科学领域:
- 麻醉学 麻醉学
- 术后恢复 术后恢复
- 药理学 药理学是指药理学的学科.
背景情况:
- 腰部手术通常会导致术后疼痛,阿片类药物使用增加和肠道功能延迟.
- 需要有效的策略来缓解这些常见的手术并发症.
研究的目的:
- 评估静脉注射利多卡因输液在增强腰椎手术后肠功能恢复方面的疗效.
- 评估利多卡因对疼痛管理和阿片类药物消费的影响.
主要方法:
- 一项多中心,随机,双盲,受控的研究,涉及96名年龄在60-80岁的患者进行腰部手术.
- 患者接受了静脉注射利多卡因输液或盐水安慰剂,作为他们的术前和术后疼痛管理的一部分.
- 主要结局是第一次排便的时间;次要结局包括疼痛评分,阿片类药物消耗和PONV发病率.
主要成果:
- 与对照组 (23小时) 相比,利多卡因组的第一次疏散时间 (17小时) 显著缩短.
- 在手术期间的阿片类药物消费 (sufentanil和remifentanil) 和propofol的使用在利多卡因组明显较低.
- 在两组之间的其他次要结果中没有发现显著差异.
结论:
- 静脉输注利多卡因在经历腰部手术的患者中有效地加速术后肠功能恢复.
- 利多卡因的使用减少了手术期间的阿片类药物需求,有助于改善手术恢复.
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