长期COVID和症状持续性在离院后的Omicron患者:对C-反应蛋白的洞察力
Jiankang Wu1,2,3,4, Naishu Xie1,2,3,4, Weiwei Meng1,2,3,4
1Department of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
住院的Omicron幸存者经常经历持续的长期COVID症状,如疲劳和打,长达一年. 关键的死亡预测因素包括年龄,ICU入院和糖尿病,CRP水平升高表明症状持续的风险更高.
科学领域:
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
- 关键护理医学 关键护理医学
背景情况:
- 对于Omicron变种感染的长期健康后果,特别是住院患者的持续性长期COVID,仍未得到充分研究.
- 了解Omicron后的健康轨迹对于患者管理和公共卫生战略至关重要.
研究的目的:
- 在住院患者中调查Omicron感染对健康的长期影响.
- 为了确定死亡率和持续症状 (长期COVID) 的预测因素.
- 为了确定最佳的C-反应蛋白 (CRP) 水平作为潜在的症状持续性的预测标记.
主要方法:
- 在出院6个月和1年后,对410名因Omicron感染住院的患者进行前性随访.
- 用单变量和多变量分析来确定死亡率预测因素和症状趋势.
- 分析C-反应蛋白 (CRP) 水平及其与症状持续性的关联.
主要成果:
- 在410名患者中,59人死亡. 死亡率预测因素包括晚年,ICU入院和糖尿病.
- 在出院6个月和1年后,分别有86.0%和83.5%的幸存者报告至少一个症状,最常见的是疲劳,咳和打.
- 有症状的患者表现出更长的住院时间,淋巴缺血和CRP水平升高;CRP水平≥15.38 mg/L与持续症状的风险更高有关.
结论:
- 住院的Omicron幸存者面临着长时间的症状持续时间,与ICU入院,年龄和糖尿病相关的显著死亡风险.
- 疲劳和打等持续症状很常见,尽管随着时间的推移整体减少.
- 症状患者的CRP水平升高和长时间住院强调需要针对高风险个体进行长期监测和干预.
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